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Kyun-Hwan Kim
Konkuk University
80Publications
22H-index
1,192Citations
Publications 83
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Hepatitis B virus (HBV) infection is a major factor in the development of various liver diseases such as hepatocellular carcinoma (HCC). Among HBV encoded proteins, HBV X protein (HBx) is known to play a key role in the development of HCC. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear transcription factor which is critical for hepatocyte differentiation. However, the expression level as well as its regulatory mechanism in HBV infection have yet to be clarified. Here, we observed the suppress...
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#1Young-Sun LeeH-Index: 6
#2Eunjung KoH-Index: 2
Last.Jong Eun YeonH-Index: 24
view all 12 authors...
Alpha fetoprotein (AFP) has been used as a serologic indicator of hepatocellular carcinoma (HCC). We aimed to identify an HCC-specific serum biomarker for diagnosis using a multiplexed proteomic technique in HCC patients with normal AFP levels. A total of 152 patients were included from Guro Hospital, Korea University. Among 267 identified proteins, 28 and 86 proteins showed at least a two-fold elevation or reduction in expression, respectively. Multiple reaction monitoring (MRM) analysis of 41 ...
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#1Gu Choul Shin (Konkuk University)H-Index: 11
#2Sung Ung Moon (Sookmyung Women's University)
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 6 authors...
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#1Jeong-Hoon Lee (SNU: Seoul National University)H-Index: 24
#2Kyun-Hwan KimH-Index: 22
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#1Suhyun Park (SKKU: Sungkyunkwan University)
#2Seon In Hwang (Konkuk University)H-Index: 4
Last.Yong-Han Paik (SKKU: Sungkyunkwan University)H-Index: 21
view all 11 authors...
Until now, there is no effective anti-fibrotic therapy available for liver cirrhosis. Stem cell therapies have been studied for the treatment of hepatic fibrosis. However, the use of embryonic stem cells or induced pluripotent stem cells (iPSC) has limitations such as ethical concern or malignancy potential. Induced hepatocyte-like cells (iHEPs) generated by direct reprogramming technology may overcome these limitations. In this study, we generated iHEPs by direct reprogramming from mouse embryo...
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#1Soon Bin Kwon (Yonsei University)H-Index: 3
#2Kisun Ryu (Yonsei University)H-Index: 6
Last.Seong Il Choi (Stockholm University)H-Index: 10
view all 8 authors...
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#1Gu Choul Shin (Konkuk University)H-Index: 11
#2Sung Ung Moon (Sookmyung Women's University)
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 6 authors...
Unfolded protein response (UPR) is an adaptive mechanism that aims at restoring ER homeostasis under severe environmental stress. Malignant cells are resistant to environmental stress, which is largely due to an activated UPR. However, the molecular mechanisms by which different UPR branches are selectively controlled in tumor cells are not clearly understood. Here, we provide evidence that PRKCSH, previously known as glucosidase II beta subunit, functions as a regulator for selective activation...
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#1Soon Bin Kwon (Yonsei University)H-Index: 3
#2Kisun Ryu (Yonsei University)H-Index: 6
Last.Seong Il Choi (Stockholm University)H-Index: 10
view all 8 authors...
Molecular chaperones play an important role in cellular protein-folding assistance and aggregation inhibition. As a different but complementary model, we previously proposed that, in general, soluble cellular macromolecules with large excluded volume and surface charges exhibit intrinsic chaperone activity to prevent aggregation of their connected polypeptides irrespective of the connection type, thereby contributing to efficient protein folding. As a proof of concept, we here demonstrated that ...
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#1Sang Hoon Ahn (Yonsei University)H-Index: 46
#2Won Kim (Seoul Metropolitan Government)H-Index: 17
Last.Kwang Hyub Han (Yonsei University)H-Index: 61
view all 28 authors...
Background & Aims Besifovir dipivoxil maleate (BSV) has activity against hepatitis B virus (HBV). We performed a phase 3 study to compare the antiviral efficacy and safety of BSV vs tenofovir disoproxil fumarate (TDF) in patients with chronic HBV infection in Korea. Methods We conducted a double-blind, non-inferiority trial of 197 patients with chronic HBV infection at 22 sites in South Korea, from November 2013 through February 2016. Patients were randomly assigned to groups given BSV (150 mg, ...
2 CitationsSource
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