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Kyun-Hwan Kim
Konkuk University
Molecular biologyVirologyHepatitis BHepatitis B virusBiology
78Publications
22H-index
1,289Citations
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Publications 79
Newest
#1Suchithra Poilil Surendran (Chonnam National University)H-Index: 4
#2Reju George Thomas (Chonnam National University)H-Index: 14
Last. Yong Yeon Jeong (Chonnam National University)H-Index: 35
view all 7 authors...
: Chronic liver diseases such as hepatitis B viral (HBV) infection and liver fibrosis have been a major health problem worldwide. However, less research has been conducted owing to the lack of animal models. The key purpose of this study was to determine the effects of different hepatotoxins in HBV-affected liver. In this study, we successfully generated a combined liver fibrosis model by administering HBV 1.2 plasmid and thioacetamide/ethanol (TAA/EtOH). To our knowledge, this is the first stud...
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#1Yong Kwang Park (Center for Infectious Disease Research and Policy)H-Index: 1
#1Yong Kwang ParkH-Index: 11
Last. Byeong-Sun Choi (Center for Infectious Disease Research and Policy)H-Index: 2
view all 7 authors...
BACKGROUND AND AIM: Interferon-stimulated gene 20 (ISG20) is an interferon-inducible exonuclease that inhibits the replication of several RNA viruses. In patients with chronic hepatitis B, ISG20 expression is related to the interferon-alpha treatment response. However, the molecular mechanism of ISG20-mediated anti-hepatitis B virus (HBV) activity is unclear. METHODS: We have investigated the effect of ISG20 on antiviral activity to address that. The life cycle of HBV was analyzed by the ectopic...
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#1Soree Park (Konkuk University)H-Index: 8
#2Yea Na Ha (Konkuk University)H-Index: 3
Last. Jae Jin Shin (Konkuk University)
view all 12 authors...
Hepatitis B virus (HBV) infection is a major factor in the development of various liver diseases such as hepatocellular carcinoma (HCC). Among HBV encoded proteins, HBV X protein (HBx) is known to play a key role in the development of HCC. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear transcription factor which is critical for hepatocyte differentiation. However, the expression level as well as its regulatory mechanism in HBV infection have yet to be clarified. Here, we observed the suppress...
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#1Young Sun LeeH-Index: 7
#1Young-Sun Lee (KU: Korea University)H-Index: 20
Last. Jong Eun Yeon (KU: Korea University)H-Index: 24
view all 12 authors...
Alpha fetoprotein (AFP) has been used as a serologic indicator of hepatocellular carcinoma (HCC). We aimed to identify an HCC-specific serum biomarker for diagnosis using a multiplexed proteomic technique in HCC patients with normal AFP levels. A total of 152 patients were included from Guro Hospital, Korea University. Among 267 identified proteins, 28 and 86 proteins showed at least a two-fold elevation or reduction in expression, respectively. Multiple reaction monitoring (MRM) analysis of 41 ...
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#1Jeong-Hoon Lee (SNU: Seoul National University)H-Index: 24
#2Kyun-Hwan KimH-Index: 22
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#1Soon Bin Kwon (Yonsei University)H-Index: 4
#2Kisun Ryu (Yonsei University)H-Index: 6
Last. Seong Il Choi (Stockholm University)H-Index: 11
view all 8 authors...
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#1Gu Choul Shin (Konkuk University)H-Index: 12
#2Sung Ung Moon (Sookmyung Women's University)H-Index: 1
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 6 authors...
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#1Sang Hoon Ahn (Yonsei University)H-Index: 49
#2Won Kim (Seoul Metropolitan Government)H-Index: 26
Last. Kwang Hyub Han (Yonsei University)H-Index: 66
view all 28 authors...
Background & Aims Besifovir dipivoxil maleate (BSV) has activity against hepatitis B virus (HBV). We performed a phase 3 study to compare the antiviral efficacy and safety of BSV vs tenofovir disoproxil fumarate (TDF) in patients with chronic HBV infection in Korea. Methods We conducted a double-blind, non-inferiority trial of 197 patients with chronic HBV infection at 22 sites in South Korea, from November 2013 through February 2016. Patients were randomly assigned to groups given BSV (150 mg, ...
2 CitationsSource
#1Gu Choul Shin (Konkuk University)H-Index: 12
#2Sung Ung Moon (Sookmyung Women's University)H-Index: 1
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 6 authors...
Unfolded protein response (UPR) is an adaptive mechanism that aims at restoring ER homeostasis under severe environmental stress. Malignant cells are resistant to environmental stress, which is largely due to an activated UPR. However, the molecular mechanisms by which different UPR branches are selectively controlled in tumor cells are not clearly understood. Here, we provide evidence that PRKCSH, previously known as glucosidase II beta subunit, functions as a regulator for selective activation...
5 CitationsSource
#1Hye Min Lee (Yonsei University)H-Index: 3
#2Soon Bin Kwon (Yonsei University)H-Index: 4
Last. Baik Lin SeongH-Index: 32
view all 11 authors...
Intrinsic disorders are a common feature of hub proteins in eukaryotic interactomes controlling the signaling pathways. The intrinsically disordered proteins (IDPs) are prone to misfolding, and maintaining their functional stability remains a major challenge in validating their therapeutic potentials. Considering that IDPs are highly enriched in RNA-binding proteins (RBPs), here we reasoned and confirmed that IDPs could be stabilized by fusion to RBPs. Dickkopf2 (DKK2), Wnt antagonist and a prot...
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