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Aurélie Bedel
University of Bordeaux
16Publications
5H-index
95Citations
Publications 16
Newest
#1Grégoire Cullot (French Institute of Health and Medical Research)H-Index: 1
#2Julian Boutin (French Institute of Health and Medical Research)H-Index: 1
Last.Aurélie BedelH-Index: 5
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CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and correct congenital erythropoietic porphyria. We demonstrate that homology-directed repair is rare compared with NHEJ pathway leading to on-target indels and causing unwanted dysfunctional protein. Moreover, we describe unexpected chromosomal truncations resulting from only one Cas9 nuclease-induced DSB in cell lines and primary cells by a p53-de...
9 CitationsSource
#1Etienne Buscail (University of Bordeaux)H-Index: 2
#2Alexandre Chauvet (University of Bordeaux)H-Index: 1
Last.Sandrine Dabernat (University of Bordeaux)H-Index: 9
view all 17 authors...
Abstract Tumor-released extracellular vesicles (EVs) contain tumor-specific cargo distinguishing them from healthy EVs, and making them eligible as circulating biomarkers. Glypican 1 (GPC1)-positive exosome relevance as liquid biopsy elements is still debated. We carried out a prospective study to quantify GPC1-positive exosomes in sera from pancreatic ductal adenocarcinoma (PDAC) patients undergoing up-front surgery, as compared to controls including patients without cancer history and patients...
1 CitationsSource
#1Etienne BuscailH-Index: 1
Last.Laurence ChicheH-Index: 29
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Purpose: Expediting the diagnosis of pancreatic ductal adenocarcinoma (PDAC) would benefit care management, especially for the start of treatments requiring histological evidence. This study evaluated the combined diagnostic performance of circulating biomarkers obtained by peripheral and portal blood liquid biopsy in patients with resectable PDAC. Experimental design: Liquid biopsies were performed in a prospective translational clinical trial (PANC-CTC #NCT03032913) including 22 patients with ...
Source
#1Etienne Buscail (University of Bordeaux)H-Index: 2
#2Laurence Chiche (University of Bordeaux)H-Index: 2
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2 CitationsSource
#1Véronique Vendrely (French Institute of Health and Medical Research)H-Index: 1
#2Samuel Amintas (University of Bordeaux)H-Index: 1
Last.Sandrine Dabernat (University of Bordeaux)H-Index: 9
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Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers because it is highly resistant to every available therapeutic strategy, in particular conventional chemotherapy or radiotherapy (RT). Sensitizing tumor cells to existing treatments remains a good option to obtain fast and applicable results. Considering that ionizing radiations induce radiolysis-derived reactive oxygen species (ROS), we hypothesized that ROS-inducing bioactive food components (BFCs) could exace...
1 CitationsSource
#1V. VendrelyH-Index: 4
#2Samuel AmintasH-Index: 1
Last.Sandrine DabernatH-Index: 9
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#1Etienne BuscailH-Index: 1
Last.Sandrine DabernatH-Index: 9
view all 15 authors...
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#1Etienne BuscailH-Index: 1
#2Charline CaumontH-Index: 3
Last.Laurence ChicheH-Index: 29
view all 10 authors...
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#1Etienne BuscailH-Index: 1
#2Charline CaumontH-Index: 3
Last.Sandrine DabernatH-Index: 9
view all 12 authors...
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#1Etienne BuscailH-Index: 1
#2Pascaline QuincyH-Index: 1
Last.Sandrine DabernatH-Index: 9
view all 12 authors...
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