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Sandrine Dabernat
French Institute of Health and Medical Research
8Publications
5H-index
59Citations
Publications 8
Newest
#1Grégoire Cullot (French Institute of Health and Medical Research)H-Index: 1
#2Julian Boutin (French Institute of Health and Medical Research)H-Index: 1
Last.Aurélie BedelH-Index: 5
view all 20 authors...
CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and correct congenital erythropoietic porphyria. We demonstrate that homology-directed repair is rare compared with NHEJ pathway leading to on-target indels and causing unwanted dysfunctional protein. Moreover, we describe unexpected chromosomal truncations resulting from only one Cas9 nuclease-induced DSB in cell lines and primary cells by a p53-de...
9 CitationsSource
#1Claudia PouypoudatH-Index: 1
#2Etienne Buscail (French Institute of Health and Medical Research)H-Index: 1
Last.Véronique Vendrely (French Institute of Health and Medical Research)H-Index: 1
view all 13 authors...
Abstract Background Neoadjuvant chemoradiotherapy, potentially relevant to increase resection rate in pancreatic cancer, is still debated. Aims To assess tolerance, resection rate and outcomes of patients with non-metastatic pancreatic ductal adenocarcinoma treated by concomitant chemoradiotherapy. Methods This monocentric study included all consecutive patients treated from 2010 to 2014 for non-metastatic pancreatic adenocarcinoma. Chemotherapy was followed by chemoradiotherapy in operable pati...
1 CitationsSource
#1Etienne Buscail (French Institute of Health and Medical Research)H-Index: 1
#2O. DegrandiH-Index: 1
Last.Sandrine Dabernat (French Institute of Health and Medical Research)H-Index: 5
view all 9 authors...
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#1Aurélie Bedel (Université Bordeaux Segalen)H-Index: 5
#2Jean Max Pasquet (French Institute of Health and Medical Research)H-Index: 5
Last.François Moreau-Gaudry (Université Bordeaux Segalen)H-Index: 17
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Chronic myeloid leukemia disease (CML) found effective therapy by treating patients with tyrosine kinase inhibitors (TKI), which suppress the BCR-ABL1 oncogene activity. However, the majority of patients achieving remission with TKI still have molecular evidences of disease persistence. Various mechanisms have been proposed to explain the disease persistence and recurrence. One of the hypotheses is that the primitive leukemic stem cells (LSCs) can survive in the presence of TKI. Understanding th...
17 CitationsSource
#1Aurélie Bedel (Université Bordeaux Segalen)H-Index: 5
#2Miguel Taillepierre (Université Bordeaux Segalen)H-Index: 3
Last.François Moreau-Gaudry (Université Bordeaux Segalen)H-Index: 17
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Congenital erythropoietic porphyria (CEP) is due to a deficiency in the enzymatic activity of uroporphyrinogen III synthase (UROS); such a deficiency leads to porphyrin accumulation and results in skin lesions and hemolytic anemia. CEP is a candidate for retrolentivirus-mediated gene therapy, but recent reports of insertional leukemogenesis underscore the need for safer methods. The discovery of induced pluripotent stem cells (iPSCs) has opened up new horizons in gene therapy because it might ov...
11 CitationsSource
#1Marie Lafitte (Université Bordeaux Segalen)H-Index: 1
#2Benoit RousseauH-Index: 18
Last.Sandrine Dabernat (Université Bordeaux Segalen)H-Index: 5
view all 11 authors...
Background Pancreatic ductal adenocarcinoma is a deadly malignancy resistant to current therapies. It is critical to test new strategies, including tumor-targeted delivery of therapeutic agents. This study tested the possibility to target the transfer of a suicide gene in tumor cells using an oncotropic lentiviral vector.
12 CitationsSource
#1Camille Deplagne (French Institute of Health and Medical Research)H-Index: 1
#2Evelyne Peuchant (French Institute of Health and Medical Research)H-Index: 26
Last.Sandrine Dabernat (French Institute of Health and Medical Research)H-Index: 5
view all 5 authors...
Nm23/NDP kinases are multifunctional enzymes involved in the general homeostasis of triphosphate nucleosides. Numerous studies have shown that NDPKs also serve as regulatory factors of various cell activities, not always connected to nucleotide phosphorylation. In particular, the nme-1 gene, encoding the NM23-1/NDPKA protein, has been reported as a metastasis suppressor gene. This activity was validated in hepatocellular tumors induced in nm23-1 deficient mice. Yet, data describing the primary p...
9 CitationsSource
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