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Lichun Tang
Protein Sciences
ZygoteGeneticsHomology directed repairBiologyCRISPR
3Publications
2H-index
115Citations
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Publications 3
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#1Jin Peng (Protein Sciences)H-Index: 1
#2Lichun Tang (Protein Sciences)H-Index: 2
Last. Pumin Zhang (Protein Sciences)H-Index: 37
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: Triple-negative breast cancer (TNBC) is a malignancy that currently lacks targeted therapies. The majority of TNBCs can be characterized as basal-like and has an expression profile enriched with genes involved in DNA damage repair and checkpoint response. Here, we report that TNBC cells are under replication stress and are constantly generating DNA double-strand breaks, which is not seen in non-TNBC cells. Consequently, we found that RECQL5, which encodes a RecQ family DNA helicase involved in...
2 CitationsSource
#1Lichun Tang (Protein Sciences)H-Index: 2
#2Yanting ZengH-Index: 1
Last. Pumin Zhang (Protein Sciences)H-Index: 37
view all 7 authors...
1 CitationsSource
#1Lichun Tang (Protein Sciences)H-Index: 2
#2Yanting Zeng (Guangzhou Medical University)H-Index: 1
Last. Jian-qiao Liu (Guangzhou Medical University)H-Index: 5
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Previous works using human tripronuclear zygotes suggested that the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system could be a tool in correcting disease-causing mutations. However, whether this system was applicable in normal human (dual pronuclear, 2PN) zygotes was unclear. Here we demonstrate that CRISPR/Cas9 is also effective as a gene-editing tool in human 2PN zygotes. By injection of Cas9 protein complexed with the appropriate sgRNAs and homology donors into o...
112 CitationsSource
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