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Qingyin Liu
Northeastern University
ChemistryMitsunobu reactionCandida parapsilosisDiolTotal synthesis
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#1Qingyin Liu (NU: Northeastern University)
#2Yu Mu (NU: Northeastern University)H-Index: 7
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
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Abstract A concise total synthesis of an exceedingly potent anti-inflammatory agent violacin A as well as the preparation of thirty analogues of this lead from commercially available orcinol are described. Highlights of our synthetic efforts involve Friedel-Crafts acylation, the regioselective etherification and esterification of phenolic hydroxyl groups, and Baker-Venkatamaran rearrangement to form basic skeleton of violacin A. The deprotection reaction with Pd-catalytic was involved to avoid t...
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#1Caijuan Hu (NU: Northeastern University)H-Index: 2
#2Hao Su (NU: Northeastern University)H-Index: 2
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
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Abstract Borrelidin, a nitrile containing 18-membered polyketide macrolide, display potent antifungal activity. In this study, a library of borrelidin derivatives were synthesized. Their structures were elucidated by detailed spectroscopic data analysis. The antifungal activity and cytotoxicity of these target compounds were evaluated by broth microdilution and 3-(4,5-dimethylthiazol-2-yl)-3,5-phenytetrazoliumromide (MTT) methods. Among forty-seven prepared analogues, compound 3b had the inhibit...
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#1Qingyin Liu (NU: Northeastern University)
#2Li Han (NU: Northeastern University)H-Index: 8
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
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The first total synthesis of (±)-(1β,4β,4aβ,8aα)-4,8a-dimethylocta-hydronaphthalene-1,4a(2H)-diol (1), a degraded sesquiterpene isolated from a fermentation broth of Streptomyces albolongus, has been achieved via three different synthetic approaches (13–15 steps) starting from racemic Wieland–Miescher ketone (2). The configuration of hydroxyl groups at C-1 and C-4a in 1 was availably managed using the Mitsunobu reaction and stereo- and regioselective epoxidation. Moreover, the syntheses of confi...
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