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Sevindzh Kletukhina
Kazan Federal University
3Publications
Publications 3
Newest
Epithelial–mesenchymal transition (EMT) is a process that takes place during embryonic development, wound healing, and under some pathological processes, including fibrosis and tumor progression. The molecular changes occurring within epithelial cells during transformation to a mesenchymal phenotype have been well studied. However, to date, the mechanism of EMT induction remains to be fully elucidated. Recent findings in the field of intercellular communication have shed new light on this proces...
#1Kristina V. Kitaeva (Kazan: Kazan Federal University)H-Index: 2
#2Tikhon S. Prudnikov (Kazan: Kazan Federal University)
Last.Valeriya V. Solovyeva (Kazan: Kazan Federal University)H-Index: 3
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The tumor microenvironment is a heterogeneous population of cells actively involved in the process of growth and development of a tumor. Research has demonstrated the interactions between the different populations of cells are critical for the formation of the tumor microenvironment and, if recapitulated experimentally, can be used to produce more effective models for preclinical screening of anticancer drugs. In this study, we demonstrate co-culturing HeLa adenocarcinoma cells, peripheral blood...
#1Marina O. Gomzikova (Kazan: Kazan Federal University)H-Index: 3
#2M.O. Gomzikova (Kazan: Kazan Federal University)
Last.A Ntekim (University of Nottingham)
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Background: The cytochalasin B-induced membrane vesicles (CIMVs) are suggested to be used as a vehicle for the delivery of therapeutics. However, the angiogenic activity and therapeutic potential of human mesenchymal stem cells (MSCs) derived CIMVs (CIMVs-MSCs) remains unknown. Objectives: The objectives of this study were to analyzed the morphology, size distribution, molecular composition and angiogenic properties of CIMVs-MSCs. Methods: The morphology of CIMVs-MSC was analyzed by scanning ele...
#1Aygul Valiullina (Kazan: Kazan Federal University)H-Index: 1
#2A.S. Petukhov (Kazan: Kazan Federal University)H-Index: 3
Last.Albert A. Rizvanov (Kazan: Kazan Federal University)H-Index: 20
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Despite expanding areas of clinical application for CAR-T cell therapy there is still lack of complete information about genes responsible for tumor resistance to this type of therapy. Widely known anti-PD-1 antibody drug Nivolumab and anti-CTLA-4 antibody drug Ipilimumab represent immunotherapeutics that activate the immune system against advanced melanoma and have proven superior to cytotoxic chemotherapy. However, in addition to existing ligands (i.e. CD80, CD86, PD-L1, PD-L2) there are suppo...
#1Marina O. Gomzikova (Kazan: Kazan Federal University)H-Index: 3
#2Sevindzh Kletukhina (Kazan: Kazan Federal University)
Last.Albert A. Rizvanov (Kazan: Kazan Federal University)H-Index: 20
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Extracellular vesicles (EV) represent a promising vector system for biomolecules and drug delivery due to their natural origin and participation in intercellular communication. As the quantity of EVs is limited, it was proposed to induce the release of membrane vesicles from the surface of human cells by treatment with cytochalasin B. Cytochalasin B-induced membrane vesicles (CIMVs) were successfully tested as a vector for delivery of dye, nanoparticles, and a chemotherapeutic. However, it remai...
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