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Candice L. Downey
University of Leeds
21Publications
6H-index
134Citations
Publications 22
Newest
#1M. Ibrahim Khot (St James's University Hospital)H-Index: 2
#2Candice L. Downey (St James's University Hospital)H-Index: 6
Last.David Jayne (St James's University Hospital)H-Index: 40
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Abstract The ATP-binding cassette (ABC) superfamily G member 2 (ABCG2) transmembrane protein transporter is known for conferring resistance to treatment in cancers. Photodynamic therapy (PDT) is a promising anti-cancer method involving the use of light-activated photosensitisers to precisely induce oxidative stress and cell death in cancers. ABCG2 can efflux photosensitisers from out of cells, reducing the capacity of PDT and limiting the efficacy of treatment. Many studies have attempted to elu...
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#1Stephanie Soon (University of Leeds)
#2Hafdis S. Svavarsdottir (University of Leeds)
Last.David G Jayne (University of Leeds)H-Index: 4
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Early detection of physiological deterioration has been shown to improve patient outcomes. Due to recent improvements in technology, comprehensive outpatient vital signs monitoring is now possible. This is the first review to collate information on all wearable devices on the market for outpatient physiological monitoring. A scoping review was undertaken. The monitors reviewed were limited to those that can function in the outpatient setting with minimal restrictions on the patient’s normal life...
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#2Candice L. Downey (University of Leeds)H-Index: 6
Last.Alastair L. YoungH-Index: 11
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#1Stephen J. Chapman (University of Leeds)H-Index: 12
#2M. Aldaffaa (University of Leeds)
Last.David Jayne (University of Leeds)H-Index: 40
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#1Candice L. Downey (University of Leeds)H-Index: 6
#2Shu Ng (University of Leeds)
Last.David Wong (University of Manchester)H-Index: 7
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Objective To validate whether a wearable remote vital signs monitor could accurately measure heart rate (HR), respiratory rate (RR) and temperature in a postsurgical patient population at high risk of complications. Design Manually recorded vital signs data were paired with vital signs data derived from the remote monitor set in patients participating in the Trial of Remote versus Continuous INtermittent monitoring (TRaCINg) study: a trial of continuous remote vital signs monitoring. Setting St ...
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#1Elena Mancuso (Ulster University)H-Index: 3
#2Candice L. Downey (University of Leeds)H-Index: 6
Last.Peter R. Culmer (University of Leeds)H-Index: 13
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2 CitationsSource
#1Candice L. Downey (St James's University Hospital)H-Index: 6
#2Julie Croft (University of Leeds)H-Index: 6
Last.David Jayne (St James's University Hospital)H-Index: 40
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Background Despite medical advances, major surgery remains high risk. Up to 44% of patients experience postoperative complications, which can have huge impacts for patients and the healthcare system. Early recognition of postoperative complications is crucial in reducing morbidity and preventing long-term disability. The current standard of care is intermittent manual vital signs monitoring, but new wearable remote monitors offer the benefits of continuous vital signs monitoring without limiting...
2 CitationsSource
#1Candice L. Downey (St James's University Hospital)H-Index: 6
#2Stephen J. Chapman (St James's University Hospital)H-Index: 12
Last.David Jayne (St James's University Hospital)H-Index: 40
view all 5 authors...
Abstract Background Continuous vital signs monitoring on general hospital wards may allow earlier detection of patient deterioration and improve patient outcomes. This systematic review will assess if continuous monitoring is practical outside of the critical care setting, and whether it confers any clinical benefit to patients. Methods MEDLINE ® , MEDLINE ® In-Process, EMBASE, CINAHL and The Cochrane Library were searched for articles that evaluated the clinical or non-clinical outcomes of cont...
3 CitationsSource
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