Match!
Anna J. Stevenson
University of Edinburgh
19Publications
3H-index
41Citations
Publications 26
Newest
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
Last.Andrew M. McIntosh (Edin.: University of Edinburgh)H-Index: 75
view all 14 authors...
Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. These include methylation-based predictors of chronological age (HorvathAge, HannumAge), all-cause mortality (DNAm PhenoAge, DNAm GrimAge) and telomere length (DNAm Telomere Length). In this study, we test the association between these epigenetic markers of ageing and the prevalence and inc...
Source
#2Futao ZhangH-Index: 12
Last.Archie CampbellH-Index: 24
view all 22 authors...
Source
#2Futao ZhangH-Index: 12
Last.Riccardo E. MarioniH-Index: 40
view all 22 authors...
Availability of Data and Material According to the terms of consent for GS participants, access to individual-level data (omics and phenotypes) must be reviewed by the GS Access Committee. Applications should be made to access@generationscotland.org. Full summary statistics for the analyses presented are publicly available online at https://doi.org/10.7488/ds/2709. Funding GS received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the S...
Source
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 23 authors...
Individuals of the same chronological age exhibit disparate rates of biological ageing. Consequently, a number of methodologies have been proposed to determine biological age and primarily exploit variation at the level of DNA methylation (DNAm). A novel epigenetic clock, termed ‘DNAm GrimAge’ has outperformed its predecessors in predicting the risk of mortality as well as many age-related morbidities. However, the association between DNAm GrimAge and cognitive or neuroimaging phenotypes remains...
2 CitationsSource
#1Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 11 authors...
The identification of biomarkers that discriminate individual ageing trajectories is a principal target of ageing research. Some of the most promising predictors of biological ageing have been developed using DNA methylation. One recent candidate, which tracks age-related phenotypes in addition to chronological age, is ‘DNAm PhenoAge’. Here, we performed a phenome-wide association analysis of this biomarker in a cohort of older adults to assess its relationship with a comprehensive set of both h...
1 CitationsSource
#1Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 15 authors...
Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P < 5.4 × 10−10) loci for 33 ...
Source
#1Eleanor K. Pickett (Edin.: University of Edinburgh)H-Index: 5
#2Abigail G. Herrmann (Edin.: University of Edinburgh)H-Index: 9
Last.Tara L. Spires-Jones (Edin.: University of Edinburgh)H-Index: 43
view all 30 authors...
Summary A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes. Within a mouse tau-deficient background, we probed the molecular, cellular, and behavioral disruption triggered by the influence of wild-type human tau on human Aβ-induced pathology. We find that Aβ and tau work cooperatively to cause a hyperactivity ...
Source
#1Anne Seeboth (Edin.: University of Edinburgh)H-Index: 1
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 11 authors...
DNA methylation outlier burden has been suggested as a potential marker of biological age. An outlier is typically defined as DNA methylation levels at any one CpG site that are three times beyond the inter-quartile range from the 25th or 75th percentiles compared to the rest of the population. DNA methylation outlier burden (the number of such outlier sites per individual) increases exponentially with age. However, these findings have been observed in small samples. Here, we showed an associati...
Source
#1Anna J. Stevenson (Edin.: University of Edinburgh)H-Index: 3
#2Daniel L. McCartney (Edin.: University of Edinburgh)H-Index: 5
Last.Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 40
view all 16 authors...
Results from large cohort studies investigating the association between inflammation and cognition have been mixed, possibly due to methodological disparities. However, a key issue in research utilising inflammatory biomarkers is their typically phasic responses. C-reactive protein (CRP) is widely used to investigate the association between chronic inflammation and cognition, but its plasma concentrations can markedly deviate in response to acute infection. Recently a large-scale epigenome-wide ...
Source
#1Makis Tzioras (Edin.: University of Edinburgh)H-Index: 3
#2Michael J. D. Daniels (Edin.: University of Edinburgh)H-Index: 7
Last.Tara L. Spires-Jones (Edin.: University of Edinburgh)H-Index: 43
view all 16 authors...
Synapse loss correlates strongly with cognitive decline in Alzheimer9s disease, but the mechanisms underpinning this phenomenon remain unclear. Recent evidence from mouse models points to microglial cells as mediators of synapse removal, and human genetic evidence implicates microglia in disease risk. Here we demonstrate that microglia from human post-mortem brain contain synaptic proteins and that greater amounts are observed in microglia from Alzheimer9s compared to non-diseased brain tissue. ...
Source
123