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Kai Jiang
Chalmers University of Technology
Molecular biologyChemistryNucleic acidDNABiology
12Publications
4H-index
68Citations
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Publications 13
Newest
#1Bobo Feng (Chalmers University of Technology)H-Index: 5
#2Robert P. Sosa (University of California, Berkeley)H-Index: 1
Last. Bengt Nordén (Chalmers University of Technology)H-Index: 71
view all 11 authors...
Hydrophobic base stacking is a major contributor to DNA double-helix stability. We report the discovery of specific unstacking effects in certain semihydrophobic environments. Water-miscible ethylene glycol ethers are found to modify structure, dynamics, and reactivity of DNA by mechanisms possibly related to a biologically relevant hydrophobic catalysis. Spectroscopic data and optical tweezers experiments show that base-stacking energies are reduced while base-pair hydrogen bonds are strengthen...
2 CitationsSource
#1Kai JiangH-Index: 4
#2Sandra RochaH-Index: 22
Last. Fredrik WesterlundH-Index: 25
view all 7 authors...
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#1Kai JiangH-Index: 4
#2Nicolas HumbertH-Index: 7
Last. Fredrik WesterlundH-Index: 25
view all 7 authors...
The nucleocapsid protein NC is a crucial component in the human immunodeficiency virus type 1 life cycle. It functions both in its processed mature form and as part of the polyprotein Gag that plays a key role in the formation of new viruses. NC can protect nucleic acids (NAs) from degradation by compacting them to a dense coil. Moreover, through its NA chaperone activity, NC can also promote the most stable conformation of NAs. Here, we explore the balance between these activities for NC and Ga...
1 CitationsSource
#1Kai Jiang (Chalmers University of Technology)H-Index: 4
#2Sandra Rocha (Chalmers University of Technology)H-Index: 22
Last. Fredrik Westerlund (Chalmers University of Technology)H-Index: 25
view all 7 authors...
Published by Wiley-VCH Verlag GmbH & Co. KGaA. Fundamental research on Parkinson's disease (PD) most often focuses on the ability of α-synuclein (aS) to form oligomers and amyloids, and how such species promote brain cell death. However, there are indications that aS also plays a gene-regulatory role in the cell nucleus. Here, the interaction between monomeric aS and DNA in vitro has been investigated with single-molecule techniques. Using a nanofluidic channel system, it was discovered that aS ...
2 CitationsSource
#1Andreas Schmitt (Umeå University)H-Index: 1
#2Kai Jiang (Chalmers University of Technology)H-Index: 4
Last. Ronnie P.-A. Berntsson (Umeå University)H-Index: 14
view all 8 authors...
Gram-positive bacteria deploy type IV secretion systems (T4SSs) to facilitate horizontal gene transfer. The T4SSs of Gram-positive bacteria rely on surface adhesins as opposed to conjugative pili t ...
3 CitationsSource
#1Kai JiangH-Index: 4
#2Nicolas HumbertH-Index: 7
Last. Fredrik WesterlundH-Index: 25
view all 5 authors...
Source
#1Kai JiangH-Index: 4
#2Sandra RochaH-Index: 22
Last. Fredrik WesterlundH-Index: 25
view all 7 authors...
1 Citations
#1Antoine Malabirade (Université Paris-Saclay)H-Index: 5
#2Kai Jiang (NUS: National University of Singapore)H-Index: 4
Last. J Vandermaarel (NUS: National University of Singapore)H-Index: 32
view all 9 authors...
Hfq is a bacterial protein that is involved in several aspects of nucleic acids metabolism. It has been described as one of the nucleoid associated proteins shaping the bacterial chromosome, although it is better known to influence translation and turnover of cellular RNAs. Here, we explore the role of Escherichia coli Hfq's C-terminal domain in the compaction of double stranded DNA. Various experimental methodologies, including fluorescence microscopy imaging of single DNA molecules confined in...
10 CitationsSource
#1Antoine MalabiradeH-Index: 5
#2Kai JiangH-Index: 4
Last. J VandermaarelH-Index: 32
view all 9 authors...
Hfq is a bacterial protein that is involved in several aspects of nucleic acids metabolism. It has been described as one of the nucleoid associated proteins shaping the bacterial chromosome, although it is better known to influence translation and turnover of cellular RNAs. Here, we explore the role of Escherichia coli Hfq C-terminal domain in the compaction of double stranded DNA. Various experimental methodologies, including fluorescence microscopy imaging of single DNA molecules confined insi...
#1J Vandermaarel (NUS: National University of Singapore)H-Index: 32
#2Kai Jiang (NUS: National University of Singapore)H-Index: 4
Last. Jeroen A. van Kan (NUS: National University of Singapore)H-Index: 15
view all 4 authors...
Hfq is a bacterial pleiotropic regulator that mediates several aspects of nucleic acids metabolism. The protein notably influences translation and turnover of cellular RNAs. Although most previous contributions concentrated on Hfq's interaction with RNA, its association to DNA has also been observed in vitro and in vivo. Here, we focus on DNA-compacting properties of the Hfq hexamer as well as the NTR and CTR regions. Various experimental technologies, including fluorescence microscopy imaging o...
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