Diana Farhat
French Institute of Health and Medical Research
Warburg effectCancerCitric acid cycleGlycolysisCancer cell
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Publications 3
#1Diana FarhatH-Index: 1
#2Sandra E. Ghayad (Lebanese University)H-Index: 4
Last. Hubert LincetH-Index: 11
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The beneficial effects of lipoic acid (LA) in cancer treatment have been well documented in the last decade. Indeed, LA exerts crucial antiproliferative effects by reducing breast cancer cell viability, cell cycle progression and the epithelial-to-mesenchymal transition (EMT). However, the mechanisms of action (MOA) underlying these antiproliferative effects remain to be elucidated. Recently, we demonstrated that LA decreases breast cancer cell proliferation by inhibiting IGF-1R maturation via t...
#1Diana FarhatH-Index: 1
#2Sophie LéonH-Index: 2
Last. Hubert LincetH-Index: 11
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Breast cancer is the second most common cancer in the world. Despite advances in therapies, the mechanisms of resistance remain the underlying cause of morbidity and mortality. Lipoic acid (LA) is an antioxidant and essential cofactor in oxidative metabolism. Its potential therapeutic effects have been well documented, but its mechanisms of action (MOA) are not fully understood. The aim of this study is to validate the inhibitory LA effect on the proliferation of various breast cancer cell lines...
1 CitationsSource
#1Philippe Icard (UNICAEN: University of Caen Lower Normandy)H-Index: 10
#2Seth ShulmanH-Index: 1
Last. Hubert Lincet (French Institute of Health and Medical Research)H-Index: 4
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Abstract Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic metabolism. However, their proliferation is marked by a shift towards increasing glycolytic metabolism even in the presence of O 2 (Warburg effect). HIF1, a major hypoxia induced transcription factor, promotes a dissociation between glycolysis and the tricarboxylic acid cycle, a process limiting the efficient production of ATP and citrate which otherwise would arrest glycolysis. The Warburg effect also f...
16 CitationsSource