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Ferdinand C. Breedveld
Leiden University Medical Center
Physical therapyRheumatologyImmunologyRheumatoid arthritisMedicine
144Publications
61H-index
17.8kCitations
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Publications 142
Newest
#1Jonathan Kay (UMMS: University of Massachusetts Medical School)H-Index: 41
#2Thomas Dörner (Charité)H-Index: 57
Last. Ferdinand C. Breedveld (LUMC: Leiden University Medical Center)H-Index: 61
view all 5 authors...
In their correspondence, Cantini and Benucci1 voice concern regarding the recommendation of our international multidisciplinary task force on biosimilars that ‘a single switch from a bio-originator to one of its biosimilars is safe and effective.’2 This recommendation was based on consistent evidence from randomised controlled trials comparing biosimilars to their respective reference products in patients with rheumatologic diseases, in which subjects treated with a reference product were subseq...
2 CitationsSource
#1Christien RondaanH-Index: 2
#2Victoria Furer (TAU: Tel Aviv University)H-Index: 2
Last. Ori Elkayam (TAU: Tel Aviv University)H-Index: 38
view all 21 authors...
Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by efficacy, immunogenicity and safety of vaccination in adult patients with AIIRD, including those rec...
1 CitationsSource
#1Victoria FurerH-Index: 2
#2Christien RondaanH-Index: 2
Last. Ori ElkayamH-Index: 38
view all 21 authors...
Objectives The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary outcome was the incidence or prevalence of VPI in the adult AIIRD population. Meta-analysis was perfo...
2 CitationsSource
#1Tanja Stamm (Medical University of Vienna)H-Index: 40
#2Klaus P. Machold (Medical University of Vienna)H-Index: 41
Last. Josef S. Smolen (Medical University of Vienna)H-Index: 114
view all 22 authors...
Background In the present study, we explored the effects of immediate induction therapy with the anti-tumour necrosis factor (TNF)α antibody infliximab (IFX) plus methotrexate (MTX) compared with MTX alone and with placebo (PL) in patients with very early inflammatory arthritis.
6 CitationsSource
#1Edward C. Keystone (U of T: University of Toronto)H-Index: 68
#2Ferdinand C. Breedveld (LUMC: Leiden University Medical Center)H-Index: 61
Last. I. Sainsbury (AbbVie)H-Index: 2
view all 6 authors...
Objective To evaluate long-term clinical, functional and radiographic outcomes in an open-label extension (OLE) study in patients with rheumatoid arthritis (RA) receiving adalimumab monotherapy or adalimumab+methotrexate following attainment of low disease activity (LDA) with adalimumab+methotrexate. Methods Methotrexate-naive patients with early RA were randomised to adalimumab, methotrexate or adalimumab +methotrexate in a double-blind, 2-year study. Patients who completed the study and achiev...
1 CitationsSource
#1Jonathan Kay (UMMS: University of Massachusetts Medical School)H-Index: 41
#2Monika SchoelsH-Index: 19
Last. Ferdinand C. Breedveld (LUMC: Leiden University Medical Center)H-Index: 61
view all 7 authors...
The study aimed to develop evidence-based recommendations regarding the evaluation and use of biosimilars to treat rheumatological diseases. The task force comprised an expert group of specialists in rheumatology, dermatology and gastroenterology, and pharmacologists, patients and a regulator from ten countries. Four key topics regarding biosimilars were identified through a process of discussion and consensus. Using a Delphi process, specific questions were then formulated to guide a systematic...
58 CitationsSource
#2Joachim R. KaldenH-Index: 71
Last. Josef S. SmolenH-Index: 114
view all 3 authors...
1 CitationsSource
#1Edward C. Keystone (U of T: University of Toronto)H-Index: 68
#2Ferdinand C. Breedveld (LUMC: Leiden University Medical Center)H-Index: 61
Last. Arthur Kavanaugh (UCSD: University of California, San Diego)H-Index: 78
view all 11 authors...
Objective To evaluate the achievement of comprehensive disease control (CDC) following 1 year of treatment with adalimumab+methotrexate versus methotrexate alone and whether early achievement of remission (at week 24 or 26) is associated with CDC at week 52 in patients with either early or established rheumatoid arthritis (RA). Methods Post hoc analyses were conducted in three clinical studies assessing treatment with adalimumab+methotrexate: DE019 (NCT00195702) enrolled patients with establishe...
2 CitationsSource
#1Josef S Smolen (Medical University of Vienna)H-Index: 12
#2Ferdinand C. Breedveld (LUMC: Leiden University Medical Center)H-Index: 61
Last. D. van der Heijde (Leeds Teaching Hospitals NHS Trust)H-Index: 129
view all 43 authors...
Background Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routine clinical practice, but these recommendations need to be re-evaluated for appropriateness and practicability in the light of new insights. Objective To update the 2010 treat-to-t...
478 CitationsSource
#1Michaela Stoffer (Medical University of Vienna)H-Index: 9
#2Monika SchoelsH-Index: 19
Last. Tanja Stamm (Medical University of Vienna)H-Index: 40
view all 18 authors...
Objective A systematic literature review (SLR; 2009–2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations. Methods Two SLRs focused on clinical trials employing a treatment approach targeting a specific clinical outcome were performed. In addition to testing clinical, functional and/or structural changes as endpoints, comorbidities, cardiovascular risk, work productivity and educ...
257 CitationsSource
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