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Xubing Yuan
Chinese Academy of Sciences
5Publications
3H-index
29Citations
Publications 5
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#1Xubing Yuan (CAS: Chinese Academy of Sciences)H-Index: 3
#2Junping Zheng (CAS: Chinese Academy of Sciences)H-Index: 4
Last.Hongtao Liu (CAS: Chinese Academy of Sciences)H-Index: 19
view all 7 authors...
Abstract Chitosan oligosaccharides (COS) are the degraded products of chitin or chitosan prepared by chemical or enzymatic hydrolysis. As compared to chitosan, COS not only exhibit some specific physicochemical properties such as excellent water solubility, biodegradability and biocompatibility, but also have a variety of functionally biological activities including anti-inflammation, anti-bacteria, immunomodulation, neuroprotection and so on. This review aims to summarize the preparation and st...
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#1Xubing Yuan (CAS: Chinese Academy of Sciences)H-Index: 3
#2Junping Zheng (CAS: Chinese Academy of Sciences)H-Index: 4
Last.Hongtao Liu (CAS: Chinese Academy of Sciences)H-Index: 19
view all 7 authors...
Abstract The polysaccharides of Enteromorpha prolifera (PEP) displayed various bioactivities such as anti-viral, anti-inflammatory and immune-regulative effects. However, no studies were performed on the biological effect of Enteromorpha prolifera oligomers (EPO). In this study, we prepared EPO and evaluated their anti-diabetic effect. By enzymatic degradation, EPO were produced from PEP, and the average molecular weight was identified to be 44.1 kDa by Gel Permeation Chromatography (GPC) analys...
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#1Junping Zheng (CAS: Chinese Academy of Sciences)H-Index: 4
#2Xubing Yuan (CAS: Chinese Academy of Sciences)H-Index: 3
Last.Hongtao Liu (CAS: Chinese Academy of Sciences)H-Index: 19
view all 9 authors...
7 CitationsSource
#1Yibo BaiH-Index: 1
#2Junping ZhengH-Index: 4
Last.Lanyan ZhengH-Index: 1
view all 8 authors...
Chitosan oligosaccharides (COS) display various biological activities. In this study, we aimed to explore the preventive effects of COS on glucolipid metabolism disorder using palmitic acid (PA)-induced HepG2 cells and high-fat diet (HFD)-fed C57BL/6J mice as experimental models in vitro and in vivo, respectively. The results showed that COS pretreatment for 12 h significantly ameliorated lipid accumulation in HepG2 cells exposed to PA for 24 h, accompanied by a reversing of the upregulated mRNA...
3 CitationsSource
#1Junping Zheng (CAS: Chinese Academy of Sciences)H-Index: 4
#2Xubing Yuan (CAS: Chinese Academy of Sciences)H-Index: 3
Last.Hongtao Liu (CAS: Chinese Academy of Sciences)H-Index: 19
view all 9 authors...
Abstract The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose ( P 0.01) and reversed the insulin resistance ( P 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators ( P 0.05), down-regulating the lipogenesis ( P 0.01) and inhibiting the adipocyte diffe...
19 CitationsSource
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