Markus W. Löffler
University of Tübingen
26Publications
8H-index
236Citations
Publications 26
Newest
Published on Jun 21, 2018in PLOS ONE 2.77
Stefanie Huhn6
Estimated H-index: 6
(German Cancer Research Center),
Miguel Inacio da Silva Filho6
Estimated H-index: 6
(German Cancer Research Center)
+ 22 AuthorsLudmila Vodickova25
Estimated H-index: 25
(Charles University in Prague)
Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort of sporadic colorectal cancer (CRC) (1237 cases, 787 controls) for their association with CRC risk and survival. Five SNPs were found to be associated with CRC risk and eight with survival at 5% significance level. In a replicati...
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Published on Dec 1, 2018in BMC Medical Genetics 1.91
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Julia Steinhilber4
Estimated H-index: 4
+ 14 AuthorsUte Grasshoff14
Estimated H-index: 14
(University of Tübingen)
Background The PTEN-hamartoma-tumor-syndrome (PHTS) is caused by germline mutations in Phosphatase and Tensin homolog (PTEN) and predisposes to the development of several typical malignancies. Whereas PTEN mutations have been implicated in the occurrence of malignant mesotheliomas, the genetic landscape of verrucous carcinomas (VC) is largely uncharted. Both VC and malignant peritoneal mesotheliomas (MPM) are exceedingly rare and a potential link between these malignancies and PHTS has never bee...
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Published on Jul 1, 2018in Cancer Research 9.13
Sebastian P. Haen6
Estimated H-index: 6
(University of Tübingen),
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen)
+ 13 AuthorsMaik Häntschel4
Estimated H-index: 4
(University of Tübingen)
Current research has entered into an unprecedented territory of analytical possibilities represented by so called “omics” technologies, allowing the examination of patients and their individual diseases on a previously unimaginable level. This development represents a serious challenge considering established trial designs and research conduct, particularly in early phase clinical trials, since novel theranostics (biomarker based allocation therapies) in principle would allow for patient selecti...
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Published on Dec 19, 2018in Journal of Clinical Medicine
Can Yurttas1
Estimated H-index: 1
,
Giulia Hoffmann + 6 AuthorsMarkus W. Löffler8
Estimated H-index: 8
Background: Cytoreductive surgery (CRS), followed by hyperthermic intraperitoneal chemotherapy (HIPEC), combines radical surgery with abdominal heated chemotherapy, constituting a multimodal treatment approach. Since clear standards for HIPEC conduct in colorectal carcinoma (CRC) are lacking, we aimed to provide a comprehensive structured survey. Data sources and study eligibility criteria: A systematic literature search was performed in PubMed, with keywords “HIPEC” and “colorectal cancer”, acc...
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Published on Aug 15, 2018in Cancer Research 9.13
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Daniel J. Kowalewski10
Estimated H-index: 10
(University of Tübingen)
+ 15 AuthorsStefan Beckert17
Estimated H-index: 17
Immune cell infiltrates have proven highly relevant for colorectal carcinoma prognosis, making colorectal cancer a promising candidate for immunotherapy. Because tumors interact with the immune system via HLA-presented peptide ligands, exact knowledge of the peptidome constitution is fundamental for understanding this relationship. Here, we comprehensively describe the naturally presented HLA ligandome of colorectal carcinoma and corresponding nonmalignant colon (NMC) tissue. Mass spectrometry i...
2 Citations Source Cite
Published on May 1, 2017in Annals of Hematology 2.85
Sebastian P. Haen6
Estimated H-index: 6
,
Christiane Groh1
Estimated H-index: 1
+ 9 AuthorsRupert Handgretinger66
Estimated H-index: 66
Disease relapse after one or more allogeneic hematopoietic cell transplantations (HCT) represents a therapeutic challenge with all options bearing a significant morbidity and mortality. Haploidentical HCT may induce more pronounced anti-leukemic effects and was evaluated at our center in 25 consecutive patients with disease relapse after preceding HCT receiving haploidentical grafts after in vitro T cell depletion. Overall survival at 1 and 2 years was 32 and 14%, respectively. Of note, patients...
3 Citations Source Cite
Published on Jun 1, 2017in Annals of Surgical Oncology 3.86
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen)
+ 10 AuthorsHans-Georg Rammensee78
Estimated H-index: 78
(University of Tübingen)
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) is used to treat peritoneal surface malignancies with application of cytostatic drugs such as oxaliplatin (OX) after cytoreductive surgery. Despite its increased use, evidence for optimal drug dosage, and notably duration of HIPEC, is scarce.
2 Citations Source Cite
Published on May 1, 2017in Journal of Cancer Research and Clinical Oncology 3.28
Sebastian P. Haen6
Estimated H-index: 6
,
Vicky Eyb1
Estimated H-index: 1
+ 9 AuthorsHans-Georg Rammensee78
Estimated H-index: 78
Purpose Prolonged aplasia and graft failure (GF) represent life-threatening complications after hematopoietic cell transplantation (HCT) requiring suitable biomarkers for early detection and differentiation between GF and poor graft function (PGF). Uric acid (UA) is a strong immunological danger signal.
1 Citations Source Cite
Published on Sep 1, 2017in Cytokine & Growth Factor Reviews 6.39
Luigi Buonaguro29
Estimated H-index: 29
,
Andrea Mayer-Mokler3
Estimated H-index: 3
+ 19 AuthorsFranco M. Buonaguro34
Estimated H-index: 34
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Published on Jan 27, 2017in Bioinformatics 5.48
Christopher Schroeder12
Estimated H-index: 12
(University of Tübingen),
Franz J. Hilke1
Estimated H-index: 1
(University of Tübingen)
+ 3 AuthorsMarc Sturm16
Estimated H-index: 16
(University of Tübingen)
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