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Michael Kirmiz
University of California, Davis
12Publications
3H-index
53Citations
Publications 14
Newest
#1Michael KirmizH-Index: 3
#2Taryn E. Gillies (Stanford University)
Last.James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
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#1Nicholas C Vierra (UC Davis: University of California, Davis)H-Index: 1
#2Michael Kirmiz (UC Davis: University of California, Davis)H-Index: 3
Last.James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
view all 5 authors...
Author(s): Vierra, Nicholas C; Kirmiz, Michael; van der List, Deborah; Santana, L Fernando; Trimmer, James S | Abstract: The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs) is tightly regulated and highly conserved, its function remains unclear. By identifying and evaluating proteins in close sp...
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#1Jie-Xian Dong (UC Davis: University of California, Davis)
#2Yongam Lee (UC Davis: University of California, Davis)H-Index: 1
Last.James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
view all 12 authors...
Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications. Prominent uses include as intracellular antibodies or intrabodies to bind and deliver cargo to specific proteins and/or subcellular sites within cells, and as nanoscale immunolabels for enhanced tissue penetration and improved spatial imaging resolution. Here, we report the generation and validation of nAbs against ...
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#1Nicholas C Vierra (UC Davis: University of California, Davis)H-Index: 1
#2Michael Kirmiz (UC Davis: University of California, Davis)H-Index: 3
Last.James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
view all 5 authors...
The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of brain neurons, tethering the plasma membrane (PM) to the endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs) is tightly regulated and conserved across species, its function at these sites is unclear. By identifying and evaluating proteins in close spatial proximity to Kv2.1-containing EPJs, we discovered that a significant role of Kv2.1 at EPJs is to promot...
Source
#1Jie-Xian Dong (UC Davis: University of California, Davis)H-Index: 1
#2Y. LeeH-Index: 1
Last.James S. TrimmerH-Index: 68
view all 12 authors...
Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications. Prominent uses include as intracellular antibodies or intrabodies to deliver cargo to specific proteins and/or subcellular sites within cells, and as nanoscale immunolabels for enhanced tissue penetration and improved spatial imaging resolution. Here, we report the generation and validation of nAbs against a set of ...
2 CitationsSource
#1James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
#2Michael Kirmiz (UC Davis: University of California, Davis)H-Index: 3
Source
#1Michael Kirmiz (UC Davis: University of California, Davis)H-Index: 3
#2Stephanie Palacio (UC Davis: University of California, Davis)H-Index: 5
Last.James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
view all 6 authors...
Author(s): Kirmiz, M; Palacio, S; Thapa, P; King, AN; Sack, JT; Trimmer, JS | Abstract: © 2018 by The American Society for Cell Biology. The endoplasmic reticulum (ER) and plasma membrane (PM) form junctions crucial to ion and lipid signaling and homeostasis. The Kv2.1 ion channel is localized at ER-PM junctions in brain neurons and is unique among PM proteins in its ability to remodel these specialized membrane contact sites. Here, we show that this function is conserved between Kv2.1 and Kv2.2...
13 CitationsSource
#1Michael KirmizH-Index: 3
#2Nicholas C. VierraH-Index: 1
Last.James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
view all 4 authors...
Membrane contacts between endoplasmic reticulum (ER) and plasma membrane (PM), or ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium signaling and homeostasis. Recent studies have revealed proteins crucial to the formation and function of ER-PM junctions in non-neuronal cells, but little is known of the ER-PM junctions prominent in aspiny regions of mammalian brain neurons. The Kv2.1 voltage-gated potassium channel is abundantly clustered at ER-PM junctio...
21 CitationsSource
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