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G. Ciccarelli
Sapienza University of Rome
4Publications
1H-index
7Citations
Publications 4
Newest
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
Last.Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 5 authors...
Adipose tissue (AT) is one of the largest endocrine organs contributing to metabolic homeostasis. The functional pleiotropism of AT depends on its ability to secrete a large number of hormones, cytokines, extracellular matrix proteins and growth factors, all influencing many local and systemic physiological and pathophysiological processes. In condition of chronic positive energy balance, adipocyte expansion, hypoxia, apoptosis and stress all lead to AT inflammation and dysfunction, and it has b...
1 CitationsSource
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2G. Ciccarelli (Sapienza University of Rome)H-Index: 1
Last.Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 13 authors...
Abstract Background Dipeptidyl peptidase 4 (DPP4) is a key enzyme involved in the regulation of the incretin system exerted by cleaving the glucagon-like peptide 1 (GLP-1); the blockage of DPP4, exerted by the antidiabetic agents DPP4-inhibitors (DPP4-I), results in greater GLP-1 concentration and improved glycaemic control. DPP4 acts also as a pro-inflammatory molecule and mediates vascular damage in experimental models. The relationship between DPP4 activity and endothelial function in diabete...
Source
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2G. Ciccarelli (Sapienza University of Rome)H-Index: 1
Last.Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 7 authors...
Purpose Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Whether a relation exists between circulating leptin and NT levels has not been investigated yet. The aim of this study wa...
5 CitationsSource
#1Ilaria Barchetta (Sapienza University of Rome)H-Index: 12
#2Flavia Agata Cimini (Sapienza University of Rome)H-Index: 7
Last.Maria Gisella Cavallo (Sapienza University of Rome)H-Index: 23
view all 8 authors...
BACKGROUND:Procollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardiometabolic risk and progression of chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) and steatohepatitis; its association with type 2 diabetes mellitus (T2DM) has not been elucidated yet. The aim of this study was to investigate the relationship among circulating PIIINP levels, metabolic traits, and body fat distribution in subjects with T2DM with or without NAFLD. METHODS:Dat...
1 CitationsSource
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