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Yathish Ramena
5Publications
Publications 5
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Bacterial diseases like columnaris caused by Flavobacterium columnare, result in huge economic loss to aquaculture farmers. Although there are commercially available vaccines and antibiotics to control bacterial diseases, they are proven to be inefficient. Moreover, antibiotics lead to acquired resistance in bacteria, and the drug residual in fish, resulting in tight regulations for their usage. This calls for new alternative solutions that can be safe and cost-effective to prevent and treat fis...
Epithelial cells are connected to each other and the basemen membrane by junctional complexes. These complexes are made up of transmembrane proteins and they play important role in tumor suppression. Dysregulation of the junctional proteins at tight and adherens junctions results in the loss of epithelial integrity and epithelial phenotype. This leads the cells to undergo EMT because of various signaling events, activating the transcription factors that upregulate mesenchymal genes. Cancer cells...
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Aeromonas hydrophila causes infections in wide range of organisms including humans. It causes serious and life threatening lethal infections in humans. Motile aeromonas septicemia causes huge economic loss to fish farmers. Antibiotic use and abuse is a huge problem that is environmentally lethal, leading to antibiotic resistance and difficulty in treating bacterial infections. There is always a need to find new and safe alternatives to antibiotics to deal with bacterial infections. In this study...
Epithelial tissues make up most organs in the body and perform various functions like protection, excretion, secretion etc. The epithelial tissues consist of different cell type like squamous, cuboidal, glandular and columnar depending on the organ and function. These cells can be of single or multiple layers. The epithelial cells are tightly packed together and connected by junctional complexes. They are tight junctions, adherens junctions, gap junctions, desmosomes and hemi desmosomes. These j...
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Bacterial diseases like columnaris caused by Flavobacterium columnare, has huge economic impact on aquaculture industry. Proven the low efficacy of vaccines and tight regulations with antibiotic usage, there is a need for alternative therapeutics. We have previously found that methanolic extracts (50 mg/ml) from eleven herbs and spices had bactericidal effects against Flavobacterium columnare (3 × 108 CFU/ml). In the present study we determined the minimum inhibitory concentrations of all the el...
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