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Xuan Li
University of Mississippi Medical Center
5Publications
2H-index
16Citations
Publications 5
Newest
#1Haiyan Hu (UMMC: University of Mississippi Medical Center)H-Index: 1
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ping Zhu (Southern Medical University)H-Index: 6
view all 9 authors...
Abstract Carvedilol, a third generation beta blocker, is in clinical use for heart failure patients. However, besides adrenergic receptor blockade, the pharmacological effects of carvedilol on cardiomyocytes remain unknown. AMP-activated protein kinase (AMPK) is an emerging target recognized for heart failure treatment. The mechanical properties and intracellular Ca 2+ properties were measured in isolated cardiomyocyte contractile functions in response to ischemic stress. Treatment of cardiomyoc...
#1Qingguo Lu (Sichuan University)H-Index: 1
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of antidiabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injur...
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
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#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ...
#1Xu Chen (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
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Abstract Background AMP-activated Protein Kinase (AMPK) is a stress-activated kinase that protects against cardiomyocyte injury during ischemia and reperfusion. c-Jun N-terminal kinase (JNK), a mitogen activated protein kinase, is activated by ischemia and reperfusion. NF-κB is an important transcription factor involved in ischemia and reperfusion injury. Methods and Results The intrinsic activation of AMPK attenuates the inflammation which occurred during ischemia/reperfusion through the modula...
#1Lin WangH-Index: 5
#2Chelsea LuckettH-Index: 1
Last.Ji LiH-Index: 11
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Introduction: A longevity gene, sirtuin 1 (SIRT1) is a conserved NAD+-dependent protein deacetylase. AMP-activated protein kinase (AMPK) is an energy sensor. AMPK and SIRT1 signaling pathways have common activators such as caloric restriction and oxidative stress. Hypothesis: Aging-related impaired ischemic AMPK activation and increased susceptibility to ischemic insults are due to a decreased SIRT1 levels in aging. Methods: Mice were subjected to ligation of left anterior descending coronary ar...
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