Christine M. McDonald
Children's Hospital Oakland Research Institute
EndocrinologyMicronutrientMalnutritionDiabetes mellitusMedicine
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Publications 8
#1Jacqueline M. Lauer (Boston Children's Hospital)H-Index: 2
#2Christine M. McDonald (Children's Hospital Oakland Research Institute)H-Index: 1
Last. Christopher DugganH-Index: 51
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Objective To examine whether daily zinc and/or multivitamin supplementation reduce biomarkers of environmental enteric dysfunction (EED), systemic inflammation, or markers of growth in a sample of infants from Dar es Salaam, Tanzania. Study design Subgroup analysis of infants participating in a randomized, double-blind, placebo-controlled trial received daily oral supplementation of zinc, multivitamins, zinc + multivitamins, or placebo for 18 months starting at 6 weeks of age. EED (anti-flagelli...
1 CitationsSource
#1Judy McLean (UBC: University of British Columbia)H-Index: 9
#2Martina Northrup-Lyons (UBC: University of British Columbia)
Last. Stanley ZlotkinH-Index: 37
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: Micronutrient powders (MNP) are an efficacious intervention in terms of reducing anaemia among young children, yet challenges remain regarding implementation at scale. Research that can guide effective implementation of nutrition interventions and facilitate integration into existing health care platforms is needed. This paper seeks to advance the implementation science knowledge base by presenting our multiphased strategy and findings for scaling-up MNP in Rwanda. The multiphased implementati...
#1Christine M. McDonald (Children's Hospital Oakland Research Institute)H-Index: 1
#2Robert S Ackatia-Armah (UC Davis: University of California, Davis)H-Index: 3
Last. Kenneth H. Brown (BMGF: Bill & Melinda Gates Foundation)H-Index: 67
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Author(s): McDonald, Christine M; Ackatia-Armah, Robert S; Doumbia, Seydou; Kupka, Roland; Duggan, Christopher P; Brown, Kenneth H | Abstract: BACKGROUND:Moderate acute malnutrition (MAM) affects 34.1 million children globally. Treatment effectiveness is generally determined by the amount and rate of weight gain. Body composition (BC) assessment provides more detailed information on nutritional stores and the type of tissue accrual than traditional weight measurements alone. OBJECTIVE:The aim of...
#1Mia M. Blakstad (Harvard University)H-Index: 1
#2Emily R. Smith (Harvard University)H-Index: 36
Last. Christopher Duggan (Harvard University)H-Index: 51
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Objectives To evaluate the hypothesis that various maternal, socioeconomic, delivery, and infant nutritional characteristics are associated with early childhood development in young Tanzanian children. Study design We performed a prospective cohort study among 206 HIV-exposed, uninfected and 247 HIV-unexposed Tanzanian infants who had been enrolled in 2 separate micronutrient trials (NCT00197730 and NCT00421668). Trained nurses administered culturally modified Bayley Scales of Infant and Toddler...
#1Sheila Isanaka (Harvard University)H-Index: 16
#2Dale A. Barnhart (Harvard University)H-Index: 3
Last. Nicolas A. Menzies (Harvard University)H-Index: 15
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Introduction Moderate acute malnutrition (MAM) causes substantial child morbidity and mortality, accounting for 4.4% of deaths and 6.0% of disability-adjusted life years (DALY) lost among children under 5 each year. There is growing consensus on the need to provide appropriate treatment of MAM, both to reduce associated morbidity and mortality and to halt its progression to severe acute malnutrition. We estimated health outcomes, costs and cost-effectiveness of four dietary supplements for MAM t...
#1Meryl E. WastneyH-Index: 25
#2Christine M. McDonald (Children's Hospital Oakland Research Institute)H-Index: 1
Last. Janet C. King (Children's Hospital Oakland Research Institute)H-Index: 49
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Background: Zinc deficiency limits infant growth and increases susceptibility to infections, which further compromises growth. Zinc supplementation improves the growth of zinc-deficient stunted infants, but the amount, frequency, and duration of zinc supplementation required to restore growth in an individual child is unknown. A dynamic model of zinc metabolism that predicts changes in weight and length of zinc-deficient, stunted infants with dietary zinc would be useful to define effective zinc...
#1M. Munirul Islam (International Centre for Diarrhoeal Disease Research, Bangladesh)H-Index: 21
#2Christine M. McDonald (Children's Hospital Oakland Research Institute)H-Index: 1
Last. Robert E Black (Johns Hopkins University)H-Index: 118
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Zinc is essential to supporting growth in young children especially for tissues undergoing rapid cellular differentiation and turnover, such as those in the immune system and gastrointestinal tract. Therapeutic zinc supplementation has been initiated in low-income countries as part of diarrhea treatment programs to support these needs for young children, but the effects of preventive supplemental zinc as a tablet or as a multiple micronutrient powder (MNP) on child growth and diarrheal disease a...
#1Emily R. Smith (Harvard University)H-Index: 36
#2Lindsey M. Locks (Harvard University)H-Index: 8
Last. Christopher Duggan (Harvard University)H-Index: 51
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Objective To assess the relationship between breastfeeding initiation time and postneonatal mortality, morbidity, and growth through 24 months in a cohort of Tanzanian infants. Study design We included 4203 infants from 2 trials of micronutrient supplementation. We used Cox proportional hazards models or general estimating equations to estimate relative risks. Results A total of 13% of infants initiated breastfeeding >1 hour after birth (n = 536). There was no association between breastfeeding i...
3 CitationsSource