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Zuzanna Rzepka
Medical University of Silesia
8Publications
2H-index
21Citations
Publications 8
Newest
#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 5 authors...
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#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 5 authors...
Mcl-1 is a potent antiapoptotic protein and amplifies frequently in many human cancer. Currently, it is considered that the extensively expressed of Mcl-1 protein in melanoma cells is associated with rapid tumor progression, poor prognosis and low chemosensitivity. Therefore, the antiapoptotic protein Mcl-1 could be considered as a potential target for malignant melanoma treatment. The aim of this study was to assess the effect of MIM1 a specific low molecular Mcl-1 protein inhibitor and mixture...
Source
#1Jakub Rok (Medical University of Silesia)H-Index: 7
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 5 authors...
Abstract Tetracyclines belong to antimicrobial classes with the highest consumption in veterinary medicine and agriculture, which leads to the contamination of the environment and food products, as well as to antibiotic resistance and adverse drug reactions. Chloro-derivatives of tetracyclines are thought to be relatively more phototoxic than others and belong to the most frequently cited drugs as photosensitizers. Melanins are heterogenous biopolymers determining skin, hair and eye colour. They...
Source
#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 6 authors...
Abstract Fluoroquinolones were shown to be cytotoxic towards various cancer cell lines, thus representing a potentially important source of new anticancer agents. The aim of the present study was to examine the effect of moxifloxacin on cell viability, redox balance and apoptosis in both amelanotic – C32 and melanotic – COLO829 melanoma cells. Herein, we found that moxifloxacin decreases the viability of C32 and COLO829 cells in concentration- and time-dependent manner. The EC50 values were foun...
1 CitationsSource
#1Michalina Respondek (Medical University of Silesia)H-Index: 2
#2Artur Beberok (Medical University of Silesia)H-Index: 9
Last.Ewa Buszman (Medical University of Silesia)H-Index: 18
view all 6 authors...
Abstract Glioblastoma multiforme (GBM) is the most common and high aggressive malignant brain tumor. Despite evolving oncology treatment and novel chemotherapeutic agents the median survival of patients diagnosed with GBM is only 12–15 months. This grim fact highlights necessity to identify new drugs that could improve the effectiveness of GBM patients treatment. MIM1 is a specific low molecular Mcl-1 protein inhibitor able to induce Mcl-1-dependent cancer cells death. The aim of this study was ...
1 CitationsSource
#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Zuzanna Rzepka (Medical University of Silesia)H-Index: 2
Last.Dorota Wrześniok (Medical University of Silesia)H-Index: 13
view all 6 authors...
Abstract Fluoroquinolones are a known synthetic group of antibiotics that have been the subject of many research interests. This class of antibiotics was shown to be cytotoxic towards various cancer cell lines, thus representing a potentially important source of new anticancer agents. The present study was designed to examine the effect of ciprofloxacin and moxifloxacin on cell viability, redox balance and apoptosis in U87MG glioblastoma cells. Herein, we found that both fluoroquinolones decreas...
2 CitationsSource
#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Dorota Wrześniok (Medical University of Silesia)H-Index: 13
Last.Ewa Buszman (Medical University of Silesia)H-Index: 18
view all 6 authors...
11 CitationsSource
#1Artur Beberok (Medical University of Silesia)H-Index: 9
#2Dorota Wrześniok (Medical University of Silesia)H-Index: 13
Last.Ewa Buszman (Medical University of Silesia)H-Index: 18
view all 8 authors...
Abstract Background Low effectiveness of anti-melanoma therapies makes it necessary to search for new drugs that could improve or replace the standard chemotherapy. Fluoroquinolones are a group of synthetic antibiotics, used in the treatment of wide range of bacterial infections. Moreover, this class of antibiotics has shown promising anti-tumor activity in several cancer cell lines. The aim of this study was to examine the effect of ciprofloxacin on cell viability, apoptosis and cell cycle dist...
6 CitationsSource
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