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Xiaonan Yu
Zhejiang University
4Publications
2H-index
10Citations
Publications 6
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The current study aimed to investigate the influence of four supplemental zinc salts (chelated: Zn glycine; non-chelated: Zn sulfate, Zn citrate, Zn gluconate) among different zinc concentrations (30–300 μM) on cell proliferation, oxidative stress, and energy depletion in intestinal porcine jejunum epithelial cells (IPEC-J2). Different zinc salts affected cell viability in a time- and dose-dependent manner, which was mainly dependent on the uptake of intracellular Zn2+. Intracellular Zn2+ of Zn ...
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#1Xiaonan YuH-Index: 2
Last.Jie FengH-Index: 7
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This experiment was conducted to investigate the transport characteristics of iron from ferrous bisglycinate (Fe-Gly) in intestinal cells. The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated with ferrous sulfate (FeSO4) or Fe-Gly to observe the labile iron pool and determine their iron transport. The results showed that the intracellular labile iron increased significantly with Fe-Gly or FeSO4 treatment, and this phenome...
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#1Zhao Zhuo (ZJU: Zhejiang University)H-Index: 5
#2Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
Last.Jie Feng (ZJU: Zhejiang University)H-Index: 7
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This experiment was conducted to evaluate the effects of heme and non-heme iron sources on growth performances, blood parameters, tissue mineral concentration, and intestinal morphology in weanling pigs. At 25 days of age, 32 newly weaned piglets (Duroc × Landrace × Yorkshire; 8.66 ± 0.59 kg) were allocated to one of the following dietary treatments: control group (basal diet with no extra iron addition), FeSO4 group (basal diet + 100 mg Fe/kg as FeSO4), Fe-Gly group (basal diet + 100 mg Fe/kg a...
1 CitationsSource
#1Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
#2Jianan Han (ZJU: Zhejiang University)H-Index: 2
Last.Jie Feng (ZJU: Zhejiang University)H-Index: 7
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Background This experiment was conducted to study the effect of different feed enzymes (phytase, xylanase, β-glucanase) on release rate of trace elements (Fe, Cu, Mn and Zn) in 6 commonly used feedstuffs (corn, wheat, barley, soybean meal, wheat bran, wheat middlings) by using an in vitro model, simulating the digestive processes in stomach for 2 h and then in small intestine for 6 h at 39 °C.
2 CitationsSource
#1Shenglin Fang (ZJU: Zhejiang University)H-Index: 6
#2Xiaonan Yu (ZJU: Zhejiang University)H-Index: 2
Last.Jie Feng (ZJU: Zhejiang University)H-Index: 7
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Abstract Iron overload causes many diseases, while the underlying etiologies of these diseases are unclear. Cell death processes including apoptosis, necroptosis, cyclophilin D-(CypD)-dependent necrosis and a recently described additional form of regulated cell death called ferroptosis, are dependent on iron or iron-dependent reactive oxygen species (ROS). However, whether the accumulation of intracellular iron itself induces ferroptosis or other forms of cell death is largely elusive. In presen...
7 CitationsSource
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