David W. Clark
University of Edinburgh
Genome-wide association studyGenetic associationGeneticsLocus (genetics)Biology
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Publications 16
#1Robin G Walters (University of Oxford)H-Index: 3
#1David W. Clark (Edin.: University of Edinburgh)H-Index: 6
Last. James F. Wilson (Edin.: University of Edinburgh)H-Index: 107
view all 436 authors...
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32...
1 CitationsSource
#1Edmund Gilbert (RCSI: Royal College of Surgeons in Ireland)H-Index: 4
#2Seamus O'ReillyH-Index: 3
Last. James F. Wilson (Edin.: University of Edinburgh)H-Index: 107
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Britain and Ireland are known to show population genetic structure; however, large swathes of Scotland, in particular, have yet to be described. Delineating the structure and ancestry of these populations will allow variant discovery efforts to focus efficiently on areas not represented in existing cohorts. Thus, we assembled genotype data for 2,554 individuals from across the entire archipelago with geographically restricted ancestry, and performed population structure analyses and comparisons ...
3 CitationsSource
#1Andrew Bretherick (Edin.: University of Edinburgh)H-Index: 5
#2Oriol Canela-Xandri (Edin.: University of Edinburgh)H-Index: 10
Last. Chris Haley (Edin.: University of Edinburgh)H-Index: 59
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Target identification remains a crucial challenge in drug development. To enable unbiased detection of proteins and pathways that have a causal role in disease pathogenesis or progression, we propose proteome-by-phenome Mendelian Randomisation (P 2 MR). We first detected genetic variants associated with plasma concentration of 249 proteins. We then used 64 replicated variants in two-sample Mendelian Randomisation to quantify evidence of a causal role for each protein across 846 phenotypes: this ...
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last. Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read ‘paternal imprinting’ and should have read ‘maternal imprinting’. This has been corrected in both the PDF and HTML versions of the Article.
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last. Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate ≤ 0.05 of which 331 had not previously been identified. Cis and trans methylation quantitative trait loci (mQTL) regulate methylation variation through POE at 54% (399/733) of the identified POE-infl...
3 CitationsSource
#2Paul R. H. J. Timmers (Edin.: University of Edinburgh)H-Index: 5
#3Ninon Mounier (Swiss Institute of Bioinformatics)H-Index: 1
Last. David W. Clark (Edin.: University of Edinburgh)H-Index: 6
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Ageing happens to us all, and as the cabaret singer Maurice Chevalier pointed out, "old age is not that bad when you consider the alternative". Yet, the growing ageing population of most developed countries presents challenges to healthcare systems and government finances. For many older people, long periods of ill health are part of the end of life, and so a better understanding of ageing could offer the opportunity to prolong healthy living into old age. Ageing is complex and takes a long time...
10 CitationsSource
#1Richard Karlsson Linnér (VU: VU University Amsterdam)H-Index: 7
#2Pietro Biroli (UZH: University of Zurich)H-Index: 5
Last. Jonathan P. Beauchamp (U of T: University of Toronto)H-Index: 15
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Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. We identified 611 approximately independent genetic loci associated with at least one of our phenotypes, including 124 with general risk tolerance. We report evidence of substantial shared genetic influences acros...
24 CitationsSource
#2Ninon MounierH-Index: 1
Last. Fengchun ZhangH-Index: 13
view all 84 authors...
#1David W. ClarkH-Index: 6
#2Yukinori OkadaH-Index: 49
Last. James F. WilsonH-Index: 107
view all 436 authors...
#2Pietro BiroliH-Index: 5
Last. Jonathan P. BeauchampH-Index: 15
view all 388 authors...