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Jeffrey B. Warner
University of Louisville
8Publications
2H-index
18Citations
Publications 8
Newest
#1Dennis R. WarnerH-Index: 14
#2Jeffrey B. WarnerH-Index: 2
Last.Irina A. KirpichH-Index: 17
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1 CitationsSource
#1Kara H. Zirnheld (University of Louisville)H-Index: 1
#2Dennis R. Warner (University of Louisville)H-Index: 14
Last.Irina A. Kirpich (University of Louisville)H-Index: 17
view all 6 authors...
Abstract Alcoholic liver disease (ALD) comprises a spectrum of liver pathology, including steatosis, steatohepatitis, and cirrhosis. Previous work from our group and others suggests that dietary fat, both the amount and composition, plays a pivotal role in ALD development and progression; however, the impact of specific dietary fatty acids on ALD pathogenesis is not fully elucidated. Preclinical rodent models of ALD revealed the deleterious effects of omega-6 polyunsaturated fatty acids (n-6 PUF...
1 CitationsSource
#1Dennis R. WarnerH-Index: 14
#2Jeffrey B. WarnerH-Index: 2
Last.Irina A. KirpichH-Index: 17
view all 13 authors...
Source
#1Dennis R. Warner (University of Louisville)H-Index: 14
#2Huilin Liu (University of Louisville)H-Index: 3
Last.Irina A. KirpichH-Index: 17
view all 12 authors...
Alcoholic liver disease (ALD), a significant health problem, progresses through the course of several pathologies including steatosis, steatohepatitis, fibrosis, and cirrhosis. There are no effective FDA-approved medications to prevent or treat any stages of ALD, and the mechanisms involved in ALD pathogenesis are not well understood. Bioactive lipid metabolites play a crucial role in numerous pathological conditions, as well as in the induction and resolution of inflammation. Herein, a hepatic ...
4 CitationsSource
#2Dennis R. WarnerH-Index: 14
Last.Irina A. KirpichH-Index: 17
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Source
Background/Objectives Alcohol-induced liver disease (ALD) leads to significant morbidity and mortality and creates an enormous burden on the health care system. There are no effective treatment strategies for any stage of this disease, which range from steatosis, steatohepatitis, fibrosis, to the most severe stage, cirrhosis. Most chronic drinkers will develop early stages of ALD, but only a fraction will proceed to more advanced, life-threatening stages. Therefore, beyond alcohol, other factors...
#2Jeffrey B. WarnerH-Index: 2
Last.Irina A. KirpichH-Index: 17
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Both chronic and acute (binge) alcohol drinking are important health and economic concerns worldwide and prominent risk factors for the development of alcoholic liver disease (ALD). There are no FDA-approved medications to prevent or to treat any stage of ALD. Therefore, discovery of novel therapeutic strategies remains a critical need for patients with ALD. Relevant experimental animal models that simulate human drinking patterns and mimic the spectrum and severity of alcohol-induced liver path...
14 CitationsSource
#1Dennis R. WarnerH-Index: 14
Last.Irina A. Kirpich (University of Louisville)H-Index: 17
view all 6 authors...
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