Xueping Zhang
Prostate cancerCancer researchChromatinBiologyPCA3
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Publications 3
Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. In the characterization of effects of ST3-H2A2, a selective inhibitor of the STAT3 N-terminal domain (ND), we observed that the compound induced apoptotic death in cancer cells associated with robust activation of proapoptotic genes. Using ChIP and tiling human promoter arrays, we found that activation of gene expression in resp...
63 CitationsSource
#1Olga TimofeevaH-Index: 17
#2Sergey ChasovskikhH-Index: 12
Last. Anatoly DritschiloH-Index: 48
view all 13 authors...
Abstract Phosphorylation of signal transducer and activator of transcription 3 (STAT3) on a single tyrosine residue in response to growth factors, cytokines, interferons, and oncogenes activates its dimerization, translocation to the nucleus, binding to the interferon γ (gamma)-activated sequence (GAS) DNA-binding site and activation of transcription of target genes. STAT3 is constitutively phosphorylated in various cancers and drives gene expression from GAS-containing promoters to promote tumo...
79 CitationsSource
#1Olga Timofeeva (Georgetown University)H-Index: 17
#2Xueping ZhangH-Index: 3
Last. Anatoly DritschiloH-Index: 48
view all 12 authors...
African-American (AA) men experience increased risk of developing prostate cancers as well as increased mortality following treatment as compared to European-American (EA) men. The aim of our study was to identify biological factors with potential to predispose AA men to prostate tumor progression and metastasis. To identify cancer-specific gene expression patterns in AA men, we established primary prostate cancer epithelial cells from 14 AA and 13 EA men. High-throughput microarrays were used t...
51 CitationsSource