Gildas Lepennetier
Technische Universität München
Publications 12
Cytokines play multiple roles during neuro-inflammatory processes and several cytokines have been studied in the context of specific diseases. This study provides a comprehensive picture of cerebrospinal fluid (CSF) changes during neuro-inflammation by analyzing multiple cytokines in combination with immune cell subsets and standard CSF parameters. Using multiplex assays, we simultaneously measured 36 cytokines (CCL1–3, CCL7, CCL8, CCL11, CCL13, CCL19, CCL20, CCL22–27, CXCL1, CXCL2, CXCL5, CXCL6...
#1Nikolaus Feucht (TUM: Technische Universität München)H-Index: 8
#2Mathias Maier (TUM: Technische Universität München)H-Index: 12
Last.Benjamin Knier (TUM: Technische Universität München)H-Index: 11
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Background:Patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) may show alterations of retinal layer architecture as measured by optical coherence tomography. Little is known about changes in the retinal vascular network during MS.Objective:To characterize retinal vessel structures in patients with MS and CIS and to test for associations with MS disease activity.Method:In all, 42 patients with MS or CIS and 50 healthy controls underwent retinal optical coherence tomograp...
15 CitationsSource
#1Garima Garg (TUM: Technische Universität München)H-Index: 4
#2Andreas Muschaweckh (TUM: Technische Universität München)H-Index: 7
Last.Thomas Korn (TUM: Technische Universität München)H-Index: 48
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Summary Foxp3 + regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. Here, we establish a transcriptional signature of central nervous system (CNS) Treg cells that accumulate during experimental autoimmune encephalitis (EAE) and identify a pathway that maintains Treg cell function and identity during severe inflammation. This pathway is dependent on the transcriptional regulator Blimp1,...
6 CitationsSource
#1Benjamin Knier (TUM: Technische Universität München)H-Index: 11
#2Michael Hiltensperger (TUM: Technische Universität München)H-Index: 3
Last.Thomas Korn (TUM: Technische Universität München)H-Index: 48
view all 17 authors...
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. Ly6G+ cells were recruited to the CNS during experimental autoimmune encephalomyelitis (EAE), interacted with B cells that produced the cytokines GM-CSF and interleukin-6 (IL-6), and acquired properties of PMN-MDSCs in the CNS in a manner dependent on the signal transdu...
5 CitationsSource
#1Darius Häusler (University Medical Center)H-Index: 3
#2Silke Häusser-Kinzel (University Medical Center)H-Index: 2
Last.Martin Weber (University Medical Center)H-Index: 15
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The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown. Here, we studied how anti-CD20 treatment influences B cells in bone marrow, blood, lymph nodes, and spleen in models of experimental autoimmune encephalomyelitis (EAE). Anti-CD20 reduced mature B cells in all compartments examined, although a subpop...
4 CitationsSource
#1Francesco Catania (WWU: University of Münster)H-Index: 10
#2Ulrich Krohs (WWU: University of Münster)H-Index: 9
Last.Juergen Gadau (WWU: University of Münster)H-Index: 30
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Are we in the midst of a paradigm change in biology and have animals and plants lost their individuality, i.e., are even so-called ‘typical’ organisms no longer organisms in their own right? Is the study of the holobiont—host plus its symbiotic microorganisms—no longer optional, but rather an obligatory path that must be taken for a comprehensive understanding of the ecology and evolution of the individual components that make up a holobiont? Or are associated microbes merely a component of thei...
4 CitationsSource
#1Gildas Lepennetier (WWU: University of Münster)H-Index: 5
#2Francesco Catania (WWU: University of Münster)H-Index: 10
In human, mouse, and Drosophila , the spliceosomal complex U1 snRNP (U1) protects transcripts from premature cleavage and polyadenylation at proximal intronic polyadenylation signals (PAS). These U1-mediated effects preserve transcription integrity, and are known as telescripting. The watchtower role of U1 throughout transcription is clear. What is less clear is whether cleavage and polyadenylation factors (CPFs) are simply patrolled or if they might actively antagonize U1 recruitment. In addres...
3 CitationsSource
#1Béatrice Denis (Université Paris-Saclay)H-Index: 2
#2Gaëlle Claisse (Université Paris-Saclay)H-Index: 1
Last.Dominique Joly (Université Paris-Saclay)H-Index: 2
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Abstract In sexual species, mating success depends on the male’s capacity to find sexual partners and on female receptivity to mating. Mating is under evolutionary constraints to prevent interspecific mating and to maximize the reproductive success of both sexes. In Drosophila melanogaster , female receptivity to mating is mainly controlled by Sex peptide (SP, i.e . Acp70A) produced by the male accessory glands with other proteins (Acps). The transfer of SP during copulation dramatically reduces...
6 CitationsSource
#1Gildas Lepennetier (WWU: University of Münster)H-Index: 5
#2Francesco Catania (WWU: University of Münster)H-Index: 10
mRNA-associated processes and gene structure in eukaryotes are typically treated as separate research subjects. Here, we bridge this separation and leverage the extensive multidisciplinary work on Drosophila melanogaster to examine the roles that capping, splicing, cleavage/polyadenylation, and telescripting (i.e., the protection of nascent transcripts from premature cleavage/polyadenylation by the splicing factor U1) might play in shaping exon-intron architecture in protein-coding genes. Our fi...
4 CitationsSource
#1Diana Ferro (WWU: University of Münster)H-Index: 2
#2Gildas Lepennetier (WWU: University of Münster)H-Index: 5
Last.Francesco Catania (WWU: University of Münster)H-Index: 10
view all 3 authors...
In Paramecium, the regeneration of a functional somatic genome at each sexual event relies on the elimination of thousands of germline DNA sequences, known as Internal Eliminated Sequences (IESs), from the zygotic nuclear DNA. Here, we provide evidence that IESs' length and sub-terminal bases jointly modulate IES excision by affecting DNA conformation in P. tetraurelia. Our study reveals an excess of complementary base pairing between IESs' sub-terminal and contiguous sites, suggesting that IESs...
2 CitationsSource