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Sendurai A. Mani
University of Texas MD Anderson Cancer Center
138Publications
38H-index
15.1kCitations
Publications 131
Newest
#1Geraldine V. Vijay (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Na Zhao (BCM: Baylor College of Medicine)H-Index: 4
Last.Sendurai A. Mani (University of Texas MD Anderson Cancer Center)H-Index: 38
view all 21 authors...
Triple-negative breast cancers (TNBCs), which lack receptors for estrogen, progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. Consequently, patients diagnosed with TNBCs have reduced overall and disease-free survival rates compared to patients with other subtypes of breast cancer. TNBCs are characterized by the presence of cancer cells with mesenchymal properties, indicating that the epithelial to mesenchymal transition (EMT) plays a major role in the p...
3 CitationsSource
#2James M. ArnoldH-Index: 7
Last.Sendurai A. ManiH-Index: 38
view all 17 authors...
Identifying bioenergetics that facilitate the epithelial to mesenchymal transition (EMT) in breast cancer cells may uncover targets to treat incurable metastatic disease. Metastasis is the number one cause of cancer-related deaths; therefore, it is urgent to identify new treatment strategies to prevent the initiation of metastasis. To characterize the bioenergetics of EMT, we compared metabolic activities and gene expression in cells induced to differentiate into the mesenchymal state with their...
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#1Wen Jia (Rice University)H-Index: 2
#2Abhijeet Deshmukh (University of Texas MD Anderson Cancer Center)H-Index: 2
Last.Herbert Levine (Rice University)H-Index: 56
view all 5 authors...
The epithelial-mesenchymal transition (EMT) often plays a critical role in cancer metastasis and chemoresistance, and decoding its dynamics is crucial to design effective therapeutics. EMT is regulated at multiple levels – transcriptional, translational, protein stability and epigenetics; the mechanisms by which epigenetic regulation can alter the dynamics of EMT remain elusive. Here, to identify the possible effects of epigenetic regulation in EMT, we incorporate a feedback term in our previous...
4 CitationsSource
#1James M. Arnold (BCM: Baylor College of Medicine)H-Index: 7
#2Franklin Gu (BCM: Baylor College of Medicine)H-Index: 4
Last.Arun Sreekumar (BCM: Baylor College of Medicine)H-Index: 31
view all 19 authors...
An improved understanding of the biochemical alterations that accompany tumor progression and metastasis is necessary to inform the next generation of diagnostic tools and targeted therapies. Metabolic reprogramming is known to occur during the epithelial–mesenchymal transition (EMT), a process that promotes metastasis. Here, we identify metabolic enzymes involved in extracellular matrix remodeling that are upregulated during EMT and are highly expressed in patients with aggressive mesenchymal-l...
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#1Petra Den HollanderH-Index: 13
Last.Sendurai A. ManiH-Index: 38
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#1Robiya JosephH-Index: 3
#2Rama SoundararajanH-Index: 15
Last.Sendurai A. ManiH-Index: 38
view all 25 authors...
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#1Rama SoundararajanH-Index: 15
Last.Sendurai A. ManiH-Index: 38
view all 14 authors...
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#1Mohsen Fathi (UH: University of Houston)
#2Robiya Joseph (University of Texas MD Anderson Cancer Center)H-Index: 3
Last.Navin Varadarajan (UH: University of Houston)H-Index: 15
view all 10 authors...
Decades of research on exosomes, nano-sized vesicles secreted by cells, have revealed novel roles of these vesicles in the formation of pre-metastasis niches that enhances the migration of tumor cells to those sites. Paradoxically, more recent work has suggested that these tumor-derived exosomes can also have an immunostimulatory role, depending on the model studied. The rate of secretion of exosomes by single cells is likely heterogeneous, and a deep profiling of the secretion capacity of indiv...
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#1Rama SoundararajanH-Index: 15
#2Jared J. Fradette (University of Texas MD Anderson Cancer Center)H-Index: 3
Last.Sendurai A. ManiH-Index: 38
view all 21 authors...
Over the last decade, both early diagnosis and targeted therapy have improved the survival rates of many cancer patients. Most recently, immunotherapy has revolutionized the treatment options for cancers such as melanoma. Unfortunately, a significant portion of cancers (including lung and breast cancers) do not respond to immunotherapy, and many of them develop resistance to chemotherapy. Molecular characterization of non-responsive cancers suggest that an embryonic program known as epithelial-m...
2 CitationsSource
#1Rama Soundararajan (University of Texas MD Anderson Cancer Center)H-Index: 15
#2Anurag N. Paranjape (NIH: National Institutes of Health)H-Index: 10
Last.Sendurai A. Mani (University of Texas MD Anderson Cancer Center)H-Index: 38
view all 5 authors...
Abstract Neuroendocrine/Aggressive Variant Prostate Cancers are lethal variants of the disease, with an aggressive clinical course and very short responses to conventional therapy. The age-adjusted incidence rate for this tumor sub-type has steadily increased over the past 20 years in the United States, with no reduction in the associated mortality rate. The molecular networks fueling its emergence and sustenance are still obscure; however, many factors have been associated with the onset and pr...
7 CitationsSource
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