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Dominik Cysewski
Polish Academy of Sciences
20Publications
7H-index
210Citations
Publications 20
Newest
Abstract Background The post-translational protein modification via lysine residues can significantly alter its function. α2-antiplasmin, a key inhibitor of fibrinolysis, contains 19 lysine residues. Aim We sought to identify sites of glycation and acetylation in human α2-antiplasmin and test whether the competition might occur on the lysine residues of α2-antiplasmin. Methods We analyzed human α2-antiplasmin (1) untreated; (2) incubated with increasing concentrations of β- d -glucose (0, 5, 10,...
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#1Jacek Jasiecki (Gdańsk Medical University)H-Index: 7
Last.Bartosz Wasąg (Gdańsk Medical University)H-Index: 6
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While the life expectancy of the population has increased, Alzheimer’s disease (AD) has emerged as one of the greatest health problems of old age. AD is characterized by neuronal loss and cognitive decline. In the AD brain, there is a decrease in levels of acetylcholinesterase (AChE) and an increase in the levels of the related enzyme butyrylcholinesterase (BChE), that accumulate in plaques and tangles. Apolipoprotein E (ApoE) is a major cholesterol carrier and plays an important role in maintai...
2 CitationsSource
#1Marta D. Kolba (Nencki Institute of Experimental Biology)H-Index: 1
#2Wioleta Dudka (Nencki Institute of Experimental Biology)H-Index: 1
Last.Katarzyna Piwocka (Nencki Institute of Experimental Biology)H-Index: 22
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Intercellular communication within the bone marrow niche significantly promotes leukemogenesis and provides protection of leukemic cells from therapy. Secreted factors, intercellular transfer of mitochondria and the receptor–ligand interactions have been shown as mediators of this protection. Here we report that tunneling nanotubes (TNTs)—long, thin membranous structures, which have been identified as a novel mode of intercellular cross-talk—are formed in the presence of stroma and mediate trans...
1 CitationsSource
#1Bozena Kuzniewska (University of Warsaw)H-Index: 3
#2Dominik CysewskiH-Index: 7
Last.Magdalena Dziembowska (University of Warsaw)H-Index: 9
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Synapses are the regions of the neuron that enable the transmission and propagation of action potentials on the cost of high energy consumption and elevated demand for mitochondrial ATP production. The rapid changes in local energetic requirements at dendritic spines imply the role of mitochondria in the maintenance of their homeostasis. Using global proteomic analysis supported with complementary experimental approaches, we show that an important pool of mitochondrial proteins is locally produc...
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#1Anna V. Kotrys (PAN: Polish Academy of Sciences)H-Index: 1
#2Dominik Cysewski (PAN: Polish Academy of Sciences)H-Index: 7
Last.Roman J. Szczesny (PAN: Polish Academy of Sciences)H-Index: 15
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1 CitationsSource
#1Barbara Moszczuk (Medical University of Warsaw)
#2Natalia Krata (Medical University of Warsaw)H-Index: 1
Last.Krzysztof Mucha (PAN: Polish Academy of Sciences)H-Index: 12
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#1Katarzyna Skierka (Warsaw University of Technology)H-Index: 1
#2Paweł Wilamowski (Warsaw University of Technology)
Last.Joanna Cieśla (Warsaw University of Technology)H-Index: 9
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Abstract Dihydrofolate reductase (DHFR) is a prominent molecular target in antitumor, antibacterial, antiprotozoan, and immunosuppressive chemotherapies, and CK2 protein kinase is an ubiquitous enzyme involved in many processes, such as tRNA and rRNA synthesis, apoptosis, cell cycle or oncogenic transformation. We show for the first time that CK2α subunit strongly interacted with and phosphorylated DHFR in vitro. Using quartz crystal microbalance with dissipation monitoring (QCM-D) we determined...
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#1Zbigniew Pietras (PAN: Polish Academy of Sciences)H-Index: 2
#2Magdalena A. Wojcik (University of Warsaw)H-Index: 3
Last.Roman J. Szczesny (University of Warsaw)H-Index: 15
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The GC skew in vertebrate mitochondrial genomes results in synthesis of RNAs that are prone to form G-quadruplexes (G4s). Such RNAs, although mostly non-coding, are transcribed at high rates and are degraded by an unknown mechanism. Here we describe a dedicated mechanism of degradation of G4-containing RNAs, which is based on cooperation between mitochondrial degradosome and quasi-RNA recognition motif (qRRM) protein GRSF1. This cooperation prevents accumulation of G4-containing transcripts in h...
16 CitationsSource
#1Zbigniew Pietras (PAN: Polish Academy of Sciences)H-Index: 2
#2Magdalena A. Wojcik (University of Warsaw)H-Index: 3
Last.Roman J. Szczesny (PAN: Polish Academy of Sciences)H-Index: 15
view all 9 authors...
ABSTRACTTranscription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (best known as SUV3) and the ribonuclease PNPT1 (also known as PNPase), together with G4-melting protein GRSF1, is a key player in restricting antisense mtRNAs.
2 CitationsSource
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