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Bruce Cornell
Commonwealth Scientific and Industrial Research Organisation
141Publications
27H-index
3,703Citations
Publications 121
Newest
#1Evelyne Deplazes (Curtin University)H-Index: 11
#2David Poger (UQ: University of Queensland)H-Index: 13
Last.Charles G. Cranfield (UTS: University of Technology, Sydney)H-Index: 13
view all 4 authors...
At the 2017 meeting of the Australian Society for Biophysics, we presented the combined results from two recent studies showing how hydronium ions (H3O+) modulate the structure and ion permeability of phospholipid bilayers. In the first study, the impact of H3O+ on lipid packing had been identified using tethered bilayer lipid membranes in conjunction with electrical impedance spectroscopy and neutron reflectometry. The increased presence of H3O+ (i.e. lower pH) led to a significant reduction in...
2 CitationsSource
#1Thomas BerryH-Index: 5
#2Debarun DuttaH-Index: 8
Last.Charles G. CranfieldH-Index: 13
view all 11 authors...
Melimine and its derivatives are synthetic chimeric antimicrobial agents based on protamine and melittin. The binding of solubilized melimine and its derivative, with a cysteine on N-terminus, (cys-melimine) on tethered bilayer lipid membranes (tBLMs) was examined using ac electrical impedance spectroscopy. The addition of melimine and cys-melimine initially increased membrane conduction, which subsequently falls over time. The results were obtained for tBLMs comprising zwitterionic phosphatidyl...
5 CitationsSource
#1Hadeel Alobeedallah (USYD: University of Sydney)H-Index: 1
#2Bruce CornellH-Index: 27
Last.Hans G.L. Coster (USYD: University of Sydney)H-Index: 30
view all 3 authors...
Cholesterol plays an important role in regulating the properties of phospholipid bilayers and many mechanisms have been proposed to explain why cholesterol is so ubiquitous within biological membranes of animals. Here we present the results of studies on the effect of cholesterol on the electrical/dielectric properties of lipid membranes tethered to a solid substrate. These tethered bilayer lipid membranes tBLM were formed on a commercially available chemically modified gold substrate. These lip...
1 CitationsSource
#1Evelyne Deplazes (Curtin University)H-Index: 11
#2David Poger (UQ: University of Queensland)H-Index: 13
Last.Charles G. Cranfield (UTS: University of Technology, Sydney)H-Index: 13
view all 4 authors...
This work seeks to identify the mechanisms by which hydronium ions (H3O+) modulate the structure of phospholipid bilayers by studying the interactions of H3O+ with phospholipids at the molecular level. For this, we carried out multiple microsecond-long unrestrained molecular dynamics (MD) simulations of a POPC bilayer at different H3O+ concentrations. The results show that H3O+ accumulates at the membrane surface where it displaces water and forms strong and long-lived hydrogen bonds with the ph...
2 CitationsSource
#1Rajesh Kuppusamy (UNSW: University of New South Wales)H-Index: 2
#2Muhammad Yasir (UNSW: University of New South Wales)H-Index: 2
Last.Naresh Kumar (UNSW: University of New South Wales)H-Index: 45
view all 14 authors...
• New biphenyl based amphiphiliccationic peptidomimetics were synthesized and evaluated for their antibacterialactivities.
10 CitationsSource
#1Mahdi ShahmiriH-Index: 4
#2Bruce CornellH-Index: 27
Last.Adam MechlerH-Index: 25
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Aurein 1.2 is a small cationic antimicrobial peptide, one of the shortest peptides that can exert antimicrobial activity at low micromolar concentrations. Aurein 1.2 is a surface acting peptide, following the “carpet” mechanism of thresholded membrane disruption. It is generally assumed that the activity of such cationic α-helical membrane disrupting peptides is charge driven. Here, the authors show that instead of charge interactions, aromatic phenylalanine residues of the Aurein 1.2 sequence f...
5 CitationsSource
Last.Bruce CornellH-Index: 27
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Cyclotides are cyclic disulfide-rich peptides that are chemically and thermally stable and possess pharmaceutical and insecticidal properties. The activities reported for cyclotides correlate with their ability to target phosphatidylethanolamine (PE)-phospholipids and disrupt cell membranes. However, the mechanism by which this disruption occurs remains unclear. In the current study we examine the effect of the prototypic cyclotides, kalata B1 (kB1) and kalata B2 (kB2), on tethered lipid bilayer...
8 CitationsSource
#1Heba Al KhamiciH-Index: 5
Last.Stella M. ValenzuelaH-Index: 28
view all 4 authors...
The Chloride Intracellular Ion Channel (CLIC) family consists of six conserved proteins in humans. These are a group of enigmatic proteins, which adopt both a soluble and membrane bound form. CLIC1 was found to be a metamorphic protein, where under specific environmental triggers it adopts more than one stable reversible soluble structural conformation. CLIC1 was found to spontaneously insert into cell membranes and form chloride ion channels. However, factors that control the structural transit...
5 CitationsSource
#1Hadeel Alobeedallah (USYD: University of Sydney)H-Index: 1
#2Bruce CornellH-Index: 27
Last.Hans G.L. Coster (USYD: University of Sydney)H-Index: 30
view all 3 authors...
Molecularly tethered lipid bilayer membranes were constructed on a commercially available chemically modified gold substrate. This is a new and promising product that has allowed the construction of very robust lipid bilayers. Very high resolution electrical impedance spectroscopy (EIS) was used to determine the dielectric structure of the lipid bilayers and associated interfaces. The EIS data were modelled in terms of the dielectric substructure using purpose developed software. The hydrophobic...
1 CitationsSource
#1Marco MaccariniH-Index: 1
#2Erik B. Watkins (LANL: Los Alamos National Laboratory)H-Index: 15
Last.Donald K. MartinH-Index: 20
view all 6 authors...
4 CitationsSource
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