Match!
Xia Jiang
Karolinska Institutet
14Publications
5H-index
165Citations
Publications 14
Newest
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Joe Dennis (University of Cambridge)H-Index: 37
view all 333 authors...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Karoline Kuchenbaecker (UCL: University College London)H-Index: 3
view all 333 authors...
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
#1Enda M. Byrne (UQ: University of Queensland)H-Index: 31
#2Manuel A. Ferreira (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 44
Last.Georgia Chevenix-Trench (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 77
view all 9 authors...
Observational epidemiological studies have found an association between schizophrenia and breast cancer, but it is not known if the relationship is a causal one. We used summary statistics from very large genome-wide association studies of schizophrenia (n = 40675 cases and 64643 controls) and breast cancer (n = 122977 cases and 105974 controls) to investigate whether there is evidence that the association is partly due to shared genetic risk factors and whether there is evidence of a causal rel...
#1Xia Jiang (Harvard University)H-Index: 5
#2Hongyan Huang (Harvard University)H-Index: 7
Last.Peter Kraft (Harvard University)H-Index: 103
view all 0 authors...
An analysis of 409,693 UK Biobank participants recently published in Nature Medicine identified a relative 21% increase in all-cause mortality among participants who were homozygous for the Δ32 deletion in the C-C motif chemokine receptor 5 gene (CCR5). This is a timely and potentially cautionary result in light of He Jiankui9s controversial germline editing of CCR5 to induce mutations that putatively mimic the effects of Δ32, which is known to reduce the risk of HIV infection. To provide additi...
#1Haoyu Zhang (Johns Hopkins University)H-Index: 2
#2Thomas U. Ahearn (NIH: National Institutes of Health)H-Index: 11
Last.Manjeet K. Bolla (University of Cambridge)H-Index: 27
view all 0 authors...
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fac...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 1
#2Xia Jiang (KI: Karolinska Institutet)H-Index: 5
Last.Peter Kraft (Harvard University)H-Index: 103
view all 3 authors...
Abstract Vitamin D plays an essential role in human health as it influences immune function, cell proliferation, differentiation and apoptosis. Vitamin D deficiency has been associated with numerous health outcomes, including bone disease, cancer, autoimmune disease, cardiovascular conditions and more. However, the causal role of vitamin D beyond its importance for bone health remains unclear and is under much debate. Twin and familial studies from past decades have demonstrated a nontrivial her...
#1Laura Fachal (University of Cambridge)H-Index: 17
#2Hugues Aschard (Pasteur Institute)H-Index: 19
Last.Constance Turman (Harvard University)H-Index: 8
view all 341 authors...
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants (CCVs) in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium, and enri...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Paul F. O'Reilly ('KCL': King's College London)H-Index: 36
Last.Diane J. Berry (UCL: University College London)H-Index: 26
view all 103 authors...
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10−9 at rs8018720 in SEC...
#1Yazhou He (Sichuan University)H-Index: 3
#2Maria Timofeeva (Edin.: University of Edinburgh)H-Index: 12
Last.Xiangrui Meng (Edin.: University of Edinburgh)H-Index: 4
view all 27 authors...
Background Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vitamin D is modifiable, these observations have substantial clinical and public health implications. Indeed, many health agencies already recommend supplemental vitamin D. Here, we explore causality in a large Mendelian randomisation (MR) study using an improved genetic instrument ...
12