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James L. Kirkland
Boston Medical Center
12Publications
6H-index
437Citations
Publications 12
Newest
Published on Nov 22, 2017
Renuka Kandhaya-Pillai (Autonomous University of Barcelona), Francesc Miro-Mur (Autonomous University of Barcelona)+ 3 AuthorsSimó Schwartz30
Estimated H-index: 30
(Autonomous University of Barcelona)
Source Cite
Published on Jan 1, 2016
Jianrong Han10
Estimated H-index: 10
,
Gerri Waloga1
Estimated H-index: 1
+ 9 AuthorsTamara Tchkonia37
Estimated H-index: 37
Published on Jan 1, 2015
Nathan K. LeBrasseur40
Estimated H-index: 40
,
Tamara Tchkonia37
Estimated H-index: 37
,
James L. Kirkland6
Estimated H-index: 6
Population aging simultaneously highlights the remarkable advances in science, medicine, and public policy, and the formidable challenges facing society. Indeed, aging is the primary risk factor for many of the most common chronic diseases and frailty, which result in profound social and economic costs. Population aging also reveals an opportunity, i.e. interventions to disrupt the fundamental biology of aging could significantly delay the onset of age-related conditions as a group, and, as a re...
26 Citations Source Cite
Published on Jan 1, 2014
Michael B. Stout12
Estimated H-index: 12
,
Tamara Tchkonia37
Estimated H-index: 37
,
James L. Kirkland6
Estimated H-index: 6
White adipose tissue (WAT) is an immensely plastic organ that plays a vital role in regulating metabolic homeostasis and systemic inflammation. Advancing age mitigates the dynamic nature of WAT which promotes the manifestation of several lipodystrophic-associated comorbidities. Inflammation and the accumulation of senescence cells likely play a key role in this process by inhibiting adipogenesis. The reduction of WAT functional capacity with aging and the role that inflammation and cellular sene...
3 Citations Source Cite
Published on Jun 1, 2007in Experimental Gerontology 3.22
Mark J. Cartwright3
Estimated H-index: 3
(Boston Medical Center),
Tamara Tchkonia1
Estimated H-index: 1
(Boston Medical Center),
James L. Kirkland6
Estimated H-index: 6
(Boston Medical Center)
Fat mass and tissue distribution change dramatically throughout life. Fat depot sizes reach a peak by middle or early old age, followed by a substantial decline, together with fat tissue dysfunction and redistribution in advanced old age. These changes are associated with health complications, including type 2 diabetes, atherosclerosis, dyslipidemia, thermal dysregulation, and skin ulcers, particularly in advanced old age. Fat tissue growth occurs through increases in size and number of fat cell...
169 Citations Source Cite
Published on May 1, 2003
James L. Kirkland6
Estimated H-index: 6
,
Michael Stevenson3
Estimated H-index: 3
L'invention concerne des methodes d'obtention de cultures de preadipocytes humains essentiellement purs a haut rendement. L'invention concerne des cultures obtenues selon la methodologie de l'invention, ainsi que des methodes d'identification d'agents modulateurs adipogeniques, par exemple des methodes de criblage haute capacite.
Published on Oct 7, 2002
James L. Kirkland6
Estimated H-index: 6
,
Tamara Tchkonia37
Estimated H-index: 37
L'invention se rapporte a des souches de preadipocyte qui possedent un potentiel de replication et une capacite adipogenique. Plus particulierement, cette invention porte sur des preadipocytes concus de maniere a exprimer la transcriptase inverse de la telomerase (TERT). L'invention concerne aussi l'utilisation de ces cellules en tant qu'instruments de recherche dans les techniques de criblage, et en tant que reactifs therapeutiques et/ou cliniques.
Tamara Tchkonia37
Estimated H-index: 37
,
Nino Giorgadze17
Estimated H-index: 17
+ 11 AuthorsJianrong Han10
Estimated H-index: 10
Fat distribution varies among individuals with similar body fat content. Innate differences in adipose cell characteristics may contribute because lipid accumulation and lipogenic enzyme activities vary among preadipocytes cultured from different fat depots. We determined expression of the adipogenic transcription factors peroxisome proliferator activated receptor-γ (PPAR-γ) and CCAAT/enhancer binding protein-α (C/EBP-α) and their targets in abdominal subcutaneous, mesenteric, and omental preadi...
190 Citations Source Cite
Published on Jul 15, 2000in Biochemical Journal 3.86
Wen Guo2
Estimated H-index: 2
(Boston Medical Center),
Ji-Kyung Choi21
Estimated H-index: 21
(Boston Medical Center)
+ 2 AuthorsJames A. Hamilton4
Estimated H-index: 4
(Boston Medical Center)
Medium-chain triacylglycerols (MCT) are present in milk, coconut oil and other foods, and are used therapeutically in special diets for certain disorders of lipid and glucose utilization. Recently, it has become apparent that MCT are not only oxidized in the liver, but are also present in lymph and fat tissue, particularly after chronic treatment. To evaluate the influence of MCT on metabolism in fat cells, we compared incorporation of octanoate and oleate into cellular triacylglycerols of 3T3-L...
30 Citations Source Cite
James L. Kirkland6
Estimated H-index: 6
(Boston Medical Center),
Charles H. Hollenberg1
Estimated H-index: 1
(Cancer Care Ontario)
The prevalence of obesity is increasing rapidly in Western countries, and associations between obesity and atherosclerosis, diabetes, and other serious diseases are becoming increasingly apparent (Rosenbaum et al. 1997). Frustratingly little progress has been made in developing effective treatments for obesity. Appetite-suppressant drugs, dietary, and behavioral approaches so far result in either loss of only a small percent of fat mass or in transient weight loss with rebound weight gain, often...
7 Citations Source Cite
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