scinapse is loading now...
Tsutomu Sasaki
Gunma University
88Publications
27H-index
2,496Citations
Publications 88
Newest
Published on Jan 1, 2019in Molecular metabolism 6.29
Takayoshi Suga2
Estimated H-index: 2
(Gunma University),
Osamu Kikuchi23
Estimated H-index: 23
(Gunma University)
+ 9 AuthorsSatoru Kakizaki29
Estimated H-index: 29
(Gunma University)
Abstract Objectives It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of SGLT1 in α cells is also unclear. We aimed to elucidate these points that are important not only for basic research but also for clinical insight. Methods Plasma glucagon levels were assessed in the high-fat, high-sucrose diet (HFHSD) fed C57BL/6J mice treated with dapagliflozin or canagliflozin. RT-PCR, RNA s...
3 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Sho Matsui4
Estimated H-index: 4
(Gunma University),
Tsutomu Sasaki27
Estimated H-index: 27
(Gunma University)
+ 11 AuthorsAkihiro Yamanaka38
Estimated H-index: 38
(Nagoya University)
Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetylase sirtuin-1 (SIRT1) in part influences the health-promoting effects of caloric restriction by boosting fat use in peripheral tissues. Here, we show that neuronal SIRT1 shifts diet choice from sucrose to fat in mice, matching the peripheral metabolic...
2 Citations Source Cite
Published on Dec 1, 2018in Molecular Brain 3.45
Tsutomu Sasaki27
Estimated H-index: 27
(Gunma University),
Rika Numano14
Estimated H-index: 14
(Toyohashi University of Technology)
+ 4 AuthorsTadahiro Kitamura33
Estimated H-index: 33
(Gunma University)
A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obesity in mice. However, the molecular mechanism(s) underlying HFD-induced feeding pattern disturbances remain elusive. Saturated fatty acids activate microglia and cause hypothalamic inflammation. Activated microglia cause neuroinflammation, which spreads via inflammatory cytokines and gap-ju...
2 Citations Source Cite
Published on Aug 1, 2018in Aging Cell 7.63
Maryam Gulshan2
Estimated H-index: 2
(University of Toyama),
Keisuke Yaku3
Estimated H-index: 3
(University of Toyama)
+ 8 AuthorsKazuyuki Tobe66
Estimated H-index: 66
(University of Toyama)
5 Citations Source Cite
Published on May 1, 2018in Diabetes 7.27
Takayoshi Suga2
Estimated H-index: 2
,
Osamu Kikuchi23
Estimated H-index: 23
+ 6 AuthorsTadahiro Kitamura33
Estimated H-index: 33
A recent report described that sodium glucose cotransporter (SGLT) 1 and 2 were expressed in α cells, and dapagliflozin which is a specific SGLT2 inhibitor, increased plasma glucagon levels by inhibiting SGLT2 in α cells. However, it is still controversial whether SGLT2 inhibitors increase plasma glucagon levels in vivo . Here, we showed that dapagliflozin, but not canagliflozin which is a SGLT2/low-potency-SGLT1 inhibitor, increased plasma glucagon levels in mice fed a high-fat, high-sucrose di...
Source Cite
Published on Nov 1, 2017in Appetite 3.17
Tsutomu Sasaki27
Estimated H-index: 27
(Gunma University),
Yasunobu Yasoshima19
Estimated H-index: 19
(Osaka University)
+ 3 AuthorsTadahiro Kitamura33
Estimated H-index: 33
(Gunma University)
Abstract d -serine is a co-agonist of the N-methyl d -aspartate (NMDA) receptor, an important modulator of glutamatergic excitatory synaptic transmission. We previously reported that oral d -serine ingestion inhibited the intake of highly preferred food and promoted the intake of less preferred food in mice. Here, we analyzed the effects of intraperitoneal (IP) d -serine injections on feeding behavior in mice. We assessed the effects of d -serine during both the acquisition and maintenance of a ...
Source Cite
Published on Oct 20, 2017in Nutrients 4.20
Tsutomu Sasaki27
Estimated H-index: 27
We are what we eat. There are three aspects of feeding: what, when, and how much. These aspects represent the quantity (how much) and quality (what and when) of feeding. The quantitative aspect of feeding has been studied extensively, because weight is primarily determined by the balance between caloric intake and expenditure. In contrast, less is known about the mechanisms that regulate the qualitative aspects of feeding, although they also significantly impact the control of weight and health....
5 Citations Source Cite
Published on Aug 30, 2017in PLOS Genetics 5.54
Ayako Fukunaka9
Estimated H-index: 9
(Juntendo University),
Toshiyuki Fukada36
Estimated H-index: 36
(Tokushima Bunri University)
+ 15 AuthorsHisashi Naito20
Estimated H-index: 20
(Juntendo University)
Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided new insight into human brown adipocyte biology. Genetic mutations in SLC39A13/ZIP13, a member of zinc transporter family, are known to reduce adipose tissue mass in humans; however, the underlying mechanisms remains unknown. Here, we demonstrate that the Zip13-deficient mouse shows enhanced beige adipocyte biogenesis and energy expenditure,...
10 Citations Source Cite
Published on Aug 11, 2017in eLife 7.62
Eiko Iwakoshi-Ukena11
Estimated H-index: 11
(University of California, Berkeley),
Kenshiro Shikano5
Estimated H-index: 5
(Hiroshima University)
+ 9 AuthorsLance J. Kriegsfeld30
Estimated H-index: 30
(University of California, Berkeley)
Throughout history, our ancestors needed to accumulate fat to survive during times when food sources were scarce. However, for most people in the modern age, food is abundant and eating too much is a major cause of weight gain, obesity and diseases affecting the metabolism. Obesity in particular, can lead to diseases such as diabetes and heart disease. Hunger and appetite are regulated by proteins and other chemicals that act as messengers, for example insulin, and a region of the brain called t...
6 Citations Source Cite
Published on Jan 1, 2017in Journal of Physiological Sciences 2.76
Yoshiro Ishimaru10
Estimated H-index: 10
(University of Tokyo),
Chisayo Kozuka12
Estimated H-index: 12
(University of the Ryukyus)
+ 1 AuthorsTsutomu Sasaki27
Estimated H-index: 27
(Gunma University)
At the 93rd annual meeting of the Physiological Society of Japan, a symposium entitled “Expanding frontiers in weight-control research explored by young investigators” was organized. The latest research on weight control was presented by young up-and-coming investigators. The symposium consisted of the following presentations: Gastrointestinal brush cells, immunity, and energy homeostasis; Impact of a brown rice-derived bioactive product on feeding regulation and fuel metabolism; A novel G prote...
3 Citations Source Cite
123456789