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Tsutomu Sasaki
Gunma University
88Publications
27H-index
2,496Citations
Publications 88
Newest
#1Takayoshi Suga (Gunma University)H-Index: 2
#2Osamu Kikuchi (Gunma University)H-Index: 23
Last.Satoru Kakizaki (Gunma University)H-Index: 29
view all 10 authors...
Abstract Objectives It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of SGLT1 in α cells is also unclear. We aimed to elucidate these points that are important not only for basic research but also for clinical insight. Methods Plasma glucagon levels were assessed in the high-fat, high-sucrose diet (HFHSD) fed C57BL/6J mice treated with dapagliflozin or canagliflozin. RT-PCR, RNA s...
#1Sho Matsui (Gunma University)H-Index: 4
#2Tsutomu Sasaki (Gunma University)H-Index: 27
Last.Akihiro Yamanaka (Nagoya University)H-Index: 38
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Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetylase sirtuin-1 (SIRT1) in part influences the health-promoting effects of caloric restriction by boosting fat use in peripheral tissues. Here, we show that neuronal SIRT1 shifts diet choice from sucrose to fat in mice, matching the peripheral metabolic...
#1Tsutomu Sasaki (Gunma University)H-Index: 27
#2Rika Numano (TUT: Toyohashi University of Technology)H-Index: 14
Last.Tadahiro Kitamura (Gunma University)H-Index: 33
view all 7 authors...
A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obesity in mice. However, the molecular mechanism(s) underlying HFD-induced feeding pattern disturbances remain elusive. Saturated fatty acids activate microglia and cause hypothalamic inflammation. Activated microglia cause neuroinflammation, which spreads via inflammatory cytokines and gap-ju...
#1Maryam Gulshan (University of Toyama)H-Index: 2
#2Keisuke Yaku (University of Toyama)H-Index: 3
Last.Kazuyuki Tobe (University of Toyama)H-Index: 66
view all 10 authors...
#1Takayoshi SugaH-Index: 2
#2Osamu KikuchiH-Index: 23
Last.Tadahiro KitamuraH-Index: 33
view all 9 authors...
A recent report described that sodium glucose cotransporter (SGLT) 1 and 2 were expressed in α cells, and dapagliflozin which is a specific SGLT2 inhibitor, increased plasma glucagon levels by inhibiting SGLT2 in α cells. However, it is still controversial whether SGLT2 inhibitors increase plasma glucagon levels in vivo . Here, we showed that dapagliflozin, but not canagliflozin which is a SGLT2/low-potency-SGLT1 inhibitor, increased plasma glucagon levels in mice fed a high-fat, high-sucrose di...
#1Tsutomu Sasaki (Gunma University)H-Index: 27
#2Yasunobu Yasoshima (Osaka University)H-Index: 19
Last.Tadahiro Kitamura (Gunma University)H-Index: 33
view all 6 authors...
Abstract d -serine is a co-agonist of the N-methyl d -aspartate (NMDA) receptor, an important modulator of glutamatergic excitatory synaptic transmission. We previously reported that oral d -serine ingestion inhibited the intake of highly preferred food and promoted the intake of less preferred food in mice. Here, we analyzed the effects of intraperitoneal (IP) d -serine injections on feeding behavior in mice. We assessed the effects of d -serine during both the acquisition and maintenance of a ...
We are what we eat. There are three aspects of feeding: what, when, and how much. These aspects represent the quantity (how much) and quality (what and when) of feeding. The quantitative aspect of feeding has been studied extensively, because weight is primarily determined by the balance between caloric intake and expenditure. In contrast, less is known about the mechanisms that regulate the qualitative aspects of feeding, although they also significantly impact the control of weight and health....
#1Ayako Fukunaka (Juntendo University)H-Index: 9
#2Toshiyuki Fukada (Tokushima Bunri University)H-Index: 36
Last.Hisashi Naito (Juntendo University)H-Index: 20
view all 10 authors...
Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided new insight into human brown adipocyte biology. Genetic mutations in SLC39A13/ZIP13, a member of zinc transporter family, are known to reduce adipose tissue mass in humans; however, the underlying mechanisms remains unknown. Here, we demonstrate that the Zip13-deficient mouse shows enhanced beige adipocyte biogenesis and energy expenditure,...
#1Eiko Iwakoshi-Ukena (University of California, Berkeley)H-Index: 11
#2Kenshiro Shikano (Hiroshima University)H-Index: 5
Last.Lance J. Kriegsfeld (University of California, Berkeley)H-Index: 30
view all 10 authors...
Throughout history, our ancestors needed to accumulate fat to survive during times when food sources were scarce. However, for most people in the modern age, food is abundant and eating too much is a major cause of weight gain, obesity and diseases affecting the metabolism. Obesity in particular, can lead to diseases such as diabetes and heart disease. Hunger and appetite are regulated by proteins and other chemicals that act as messengers, for example insulin, and a region of the brain called t...
#1Yoshiro Ishimaru (UTokyo: University of Tokyo)H-Index: 10
#2Chisayo Kozuka (University of the Ryukyus)H-Index: 12
Last.Tsutomu Sasaki (Gunma University)H-Index: 27
view all 4 authors...
At the 93rd annual meeting of the Physiological Society of Japan, a symposium entitled “Expanding frontiers in weight-control research explored by young investigators” was organized. The latest research on weight control was presented by young up-and-coming investigators. The symposium consisted of the following presentations: Gastrointestinal brush cells, immunity, and energy homeostasis; Impact of a brown rice-derived bioactive product on feeding regulation and fuel metabolism; A novel G prote...
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