Ruo-Chia Tseng
Tzu Chi University
DNA methylationBusiness process modelingCancer researchBusiness processBiology
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Publications 4
β-catenin is a major component of the Wnt/β-catenin signaling pathway, and is known to play a role in lung tumorigenesis. β-catenin-interacting protein 1 (CTNNBIP1) is a known repressor of β-catenin transactivation. However, little is known about the role of CTNNBIP1 in lung cancer. The aim of this study was to carry out a molecular analysis of CTNNBIP1 and its effect on β-catenin signaling, using samples from lung cancer patients and various lung cancer cell lines. Our results indicate a signif...
#1Way-Ren Huang (NYMU: National Yang-Ming University)H-Index: 1
#2Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
Last. Ruo-Chia Tseng (TCU: Tzu Chi University)H-Index: 1
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Lung cancer is a leading cause of cancer mortality in Taiwan. It has been previously demonstrated that alterations to tumor suppressor genes (TSGs) are involved in the multi-step carcinogenesis process that results in the development of human cancer, including lung cancer. Both copies of the TSG must be inactivated for their function to be lost. As a result, it is important to search for the genomic regions that potentially contain TSGs and to investigate the etiological association of lung canc...
#2Ruo-Chia TsengH-Index: 1
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In this paper, we used business process modeling standards to enhance the development of a patient-safety promulgation process with a web service. A web service that is related to a work process is typically in an organization that has been designed, built and stored in a web service repository. The purpose of using a web service is that it can be shared with multiple functional units within an organization via an Intranet. This paper further develops this approach and discusses the use of a vis...
#1Ruo-Chia Tseng (TCU: Tzu Chi University)H-Index: 1
#2Jia Ming Chang (NCKU: National Cheng Kung University)H-Index: 7
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
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Introduction: SLIT2, a secreted protein, has been found to inac- tivate Cdc42 GTPase to modulate neural cell migration. However, alteration of SLIT2-mediated Cdc42 in terms of migration regulation remains undefined in esophageal squamous cell carcinoma (ESCC). Methods: We report here in ESCC cell, animal, and clinical models that SLIT2 acts as a migration suppressor and serves as a prognostic biomarker. Results: The immunohistochemistry data indicated that 31.8% (49 of 154) of tumors from ESCC p...
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