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Heiko Braak
University of Ulm
112Publications
45H-index
11.2kCitations
Publications 112
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#1Jan Kassubek (University of Ulm)H-Index: 52
#2K. Del Tredici (University of Ulm)H-Index: 2
Last.Hans-Peter Müller (University of Ulm)H-Index: 35
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#1Heiko Braak (University of Ulm)H-Index: 45
#2Simone Feldengut (University of Ulm)H-Index: 3
Last.Kelly Del Tredici (University of Ulm)H-Index: 29
view all 5 authors...
Cortical microinfarcts are the most widespread form of brain infarction but frequently remain undetected by standard neuroimaging protocols. Moreover, microinfarcts are only partially detectable in hematoxylin-eosin-stained (H and E) 4-10 µm paraffin sections at routine neuropathological examination. In this short report, we provide two staining protocols for visualizing cortical microinfarcts in 100-300 µm sections. For low-power microscopy, the first protocol combines aldehyde fuchsine stainin...
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#1Wolfgang J. Streit (UF: University of Florida)H-Index: 59
#2Heiko Braak (University of Ulm)H-Index: 45
Last.Ingo Bechmann (Leipzig University)H-Index: 32
view all 9 authors...
7 CitationsSource
#1Karin Forsberg (Umeå University)H-Index: 15
#2Yingshuang Zhang (PKU: Peking University)
Last.Deniz Yilmazer-Hanke (University of Ulm)H-Index: 16
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White matter lesions (WMLs) are a common manifestation of small vessel disease (SVD) in the elderly population. They are associated with an enhanced risk of developing gait abnormalities, poor executive function, dementia, and stroke with high mortality. Hypoperfusion and the resulting endothelial damage are thought to contribute to the development of WMLs. The focus of the present study was the analysis of the microvascular bed in SVD patients with deep WMLs (DWMLs) by using double- and triple-...
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#1Martin Gorges (University of Ulm)H-Index: 14
#2Kelly Del Tredici (University of Ulm)H-Index: 29
Last.Jan Kassubek (University of Ulm)H-Index: 52
view all 7 authors...
A sequential transaxonal disease spread of amyotrophic lateral sclerosis (ALS)-associated TDP-43 pathology in four stages has been defined by post-mortem data, which have been transferred to in vivo imaging by diffusion tensor imaging (DTI) studies. Here, we aimed to investigate whether DTI meta-data are consistent with this proposed pattern of progression in ALS. A systematic literature search using the search engines PubMed and Scopus yielded a total of 370 publications. Of these, 57 studies w...
2 CitationsSource
#1Sarah K. Kaufman (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
#2Kelly Del Tredici (University of Ulm)H-Index: 29
Last.Marc I. Diamond (UTSW: University of Texas Southwestern Medical Center)H-Index: 39
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#1Heiko Braak (University of Ulm)H-Index: 45
#2Kelly Del Tredici (University of Ulm)H-Index: 29
7 CitationsSource
#1Sarah K. Kaufman (WashU: Washington University in St. Louis)H-Index: 6
#2Kelly Del Tredici (University of Ulm)H-Index: 29
Last.Marc I. Diamond (UTSW: University of Texas Southwestern Medical Center)H-Index: 39
view all 5 authors...
Alzheimer’s disease (AD) is characterized by accumulation of tau neurofibrillary tangles (NFTs) and, according to the prion model, transcellular propagation of pathological “seeds” may underlie its progression. Staging of NFT pathology with phospho-tau antibody is useful to classify AD and primary age-related tauopathy (PART) cases. The locus coeruleus (LC) shows the earliest phospho-tau signal, whereas other studies suggest that pathology begins in the transentorhinal/entorhinal cortices (TRE/E...
29 CitationsSource
#1Heiko Braak (University of Ulm)H-Index: 45
#2Kelly Del Tredici-Braak (University of Ulm)H-Index: 1
Last.Thomas Gasser (University of Tübingen)H-Index: 86
view all 3 authors...
3 CitationsSource
#1Jan Kassubek (University of Ulm)H-Index: 52
#2Hans-Peter Müller (University of Ulm)H-Index: 35
Last.Albert C. Ludolph (University of Ulm)H-Index: 70
view all 7 authors...
Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a dissemination in a regional sequence in four anatomically defined patterns. The aim of this retrospective study was to see whether longitudinal diffusion tensor imaging (DTI) data support the pathological findings. Methods The application of DTI analysis to fibre structures that are prone to be involved at each neuropathological pattern of ALS was performed in a monocentre sample of 67 patients with ALS and 3...
16 CitationsSource
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