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Wei Ding
Southern Medical University
ApoptosisHistone deacetylaseCell growthSignal transductionProtein kinase B
1Publications
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#1Xuan-Yan Shi (Southern Medical University)H-Index: 1
#2Wei Ding (Southern Medical University)H-Index: 1
Last. Shan-Chao Zhao (Southern Medical University)H-Index: 6
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: BACKGROUND Histone deacetylase (HDAC) inhibitors are emerging as a new class of anti-cancer drugs that promote cancer cell apoptosis, and include suberoylanilide hydroxamic acid (SAHA). The aim of this study was to investigate the mechanism of SAHA-induced apoptosis in human prostate cancer cell lines, DU145 and PC-3. MATERIAL AND METHODS Cell lines, DU145 and PC-3, were studied before and after treatment with SAHA. The effects of SAHA treatment on cell proliferation were studied using the MTT...
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