Paul J. Foster
UCL Institute of Ophthalmology
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Publications 396
#1Anthony P. Khawaja (UCL Institute of Ophthalmology)H-Index: 17
#2Alasdair N Warwick (UCL: University College London)
Last. Kay Tee Kaw (University of Cambridge)H-Index: 150
view all 9 authors...
OBJECTIVES: To identify the sociodemographic, lifestyle, comorbidity and antihypertensive medication associations with the development of hospitalisation with covid-19 in an English population. DESIGN: Prospective cohort study SETTING: The population-based UK Biobank study was linked to English covid-19 test results. PARTICIPANTS: Individuals resident in England and alive in 2020. MAIN OUTCOME MEASURES: Cases (n=605) were defined by a positive covid-19 test result conducted between 16th March an...
#1Naushin Waseem (UCL Institute of Ophthalmology)H-Index: 23
#2Sancy Low (UCL Institute of Ophthalmology)
Last. Saima Usman (QMUL: Queen Mary University of London)
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Current estimates suggest 50% of glaucoma blindness worldwide is caused by primary angle-closure glaucoma (PACG) but the causative gene is not known. We used genetic linkage and whole genome sequencing to identify Spermatogenesis Associated Protein 13, SPATA13 (NM_001166271; NP_001159743, SPATA13 isoform I), also known as ASEF2 (Adenomatous polyposis coli-stimulated guanine nucleotide exchange factor 2), as the causal gene for PACG in a large seven-generation white British family showing variabl...
#1Max YatesH-Index: 8
#2R.A. Welikala (KUL: Kingston University)H-Index: 6
Last. Paul J. Foster (UCL Institute of Ophthalmology)H-Index: 64
view all 14 authors...
Both polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) have been associated with an increased future risk of cardiovascular disease (CVD).1 However, it remains uncertain whether this is a consequence of inflammatory disease or relates to a common underlying mechanism. Retinal vascular images are a sensitive measures of vascular health, which are emerging as important biomarkers of future cardiovascular risk with changes affecting arterioles and venules.2 In this study, we assess whethe...
#1Pirro G. Hysi (UCL: University College London)H-Index: 37
#2Hélène Choquet (KP: Kaiser Permanente)H-Index: 20
Last. Khanh K. Thai (KP: Kaiser Permanente)H-Index: 5
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Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired vision. We conducted a meta-analysis of genome-wide association studies (GWAS) that involved 542,934 European participants and identified 336 novel genetic loci associated with refractive error. Collectively, all associated genetic variants explain 18.4% of heritability a...
#1Qiao Fan (NUS: National University of Singapore)H-Index: 23
#2Alfred Pozarickij (Cardiff University)H-Index: 1
Last. Anthony P. Khawaja (University of Cambridge)H-Index: 17
view all 58 authors...
Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal cu...
#1Bryan C H Ang (National Healthcare Group)
#2Sophia Seen (NUS: National University of Singapore)H-Index: 2
Last. Tin AungH-Index: 75
view all 11 authors...
Background/Aims This work aimed to study the effect of long-term intraocular pressure (IOP) fluctuation on visual field (VF) progression 8 years post-trabeculectomy in Asian eyes. Methods This was a retrospective analysis of 8-year post-trabeculectomy data from The Singapore 5-Fluorouracil (5-FU) Study. VFs were analysed using Progressor software (Medisoft, Leeds, UK). Outcome measures included mean slope for VF per year, number of progressing points and mean slope for progressing points per yea...
#1Sancy Low (UCL Institute of Ophthalmology)
Last. P. A. Bloom (Imperial College London)H-Index: 11
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The availability and reduced cost of genotyping has improved gene susceptibility testing and our scientific understanding of disease pathophysiology. Whilst several personalised translational models exist within medical frameworks, genetic-based surgical therapy is a translational application not widely used in surgical specialties. We present a clinical series of five patients with genetically confirmed bestrophinopathy and malignant glaucoma (MG). Patients were followed up for 12 months or mor...
#1Puya Gharahkhani (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 12
#2Eric Jorgenson (KP: Kaiser Permanente)H-Index: 26
Last. Robert P. Igo (Case Western Reserve University)H-Index: 22
view all 76 authors...
We conducted a large multi-ethnic meta-analysis of genome-wide association studies for primary open-angle glaucoma (POAG) on a total of 34,179 cases vs 349,321 controls, and identified 127 independent risk loci, almost doubling the number of known loci for POAG. The majority of loci have broadly consistent effect across European, Asian and African ancestries. We identify a link, both genome-wide and at specific loci, between POAG and Alzheimer9s disease. Gene expression data and bioinformatic fu...
#1Jamie E. Craig (Flinders Medical Centre)H-Index: 51
#3Xikun Han (UQ: University of Queensland)H-Index: 6
Last. Uk Biobank EyeH-Index: 1
view all 59 authors...
Glaucoma, a disease characterized by progressive optic nerve degeneration, can be prevented through timely diagnosis and treatment. We characterize optic nerve photographs of 67,040 UK Biobank participants and use a multitrait genetic model to identify risk loci for glaucoma. A glaucoma polygenic risk score (PRS) enables effective risk stratification in unselected glaucoma cases and modifies penetrance of the MYOC variant encoding p.Gln368Ter, the most common glaucoma-associated myocilin variant...
2 CitationsSource
#1Luke Tanner (University of Exeter)
#2Gus Gazzard (UCL Institute of Ophthalmology)H-Index: 39
Last. Paul J. Foster (UCL Institute of Ophthalmology)H-Index: 64
view all 4 authors...
Angle-closure glaucoma is an aggressive condition that causes millions to become blind worldwide. This review explores the use of prophylactic laser peripheral iridotomy (PI) in patients classified as primary angle-closure suspects (PACS), and additionally, the use of clear lens exchange as a primary treatment option in established angle-closure disease with or without glaucoma. As PI has a strong prophylactic effect in fellow eyes of patients who have had an acute attack, its use has been widel...