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Ying-Jia Xu
Fudan University
8Publications
2H-index
18Citations
Publications 8
Newest
#1Hua Liu (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Ying-Jia Xu (Fudan University)H-Index: 2
Last.Xing-Biao Qiu (SJTU: Shanghai Jiao Tong University)H-Index: 15
view all 11 authors...
Abstract As two members of the basic helix-loop-helix family of transcription factors, HAND1 and HAND2 are both required for the embryonic cardiogenesis and postnatal ventricular structural remodeling. Recently a HAND1 mutation has been reported to cause dilated cardiomyopathy (DCM). However, the association of a HAND2 mutation with DCM is still to be ascertained. In this research, t he coding regions and splicing junction sites of the HAND2 gene were sequenced in 206 unrelated patients affected...
#1Ying-Jia Xu (Fudan University)H-Index: 2
#2Ying-Jia Xu (Fudan University)
Last.Yi-Qing Yang (Fudan University)H-Index: 1
view all 9 authors...
Dilated cardiomyopathy (DCM) is the most prevalent cause of non-ischemic cardiac failure and the commonest indication for cardiac transplantation. Compelling evidence highlights the pivotal roles of genetic defects in the occurrence of DCM. Nevertheless, the genetic determinants underpinning DCM remain largely obscure. In this study, the coding regions of ISL1, which encodes a transcription factor critical for embryonic cardiogenesis and postnatal cardiac remodeling, were sequenced in 216 unrela...
#1Lan Ma (SJTU: Shanghai Jiao Tong University)
#2Wang Jian-Guo (Tongji University)H-Index: 21
Last.Xing-Biao Qiu (SJTU: Shanghai Jiao Tong University)H-Index: 15
view all 12 authors...
Congenital heart defect (CHD) is the most common form of birth deformity and is responsible for substantial morbidity and mortality in humans. Increasing evidence has convincingly demonstrated that genetic defects play a pivotal role in the pathogenesis of CHD. However, CHD is a genetically heterogeneous disorder and the genetic basis underpinning CHD in the vast majority of cases remains elusive. This study was sought to identify the pathogenic mutation in the ISL1 gene contributing to CHD. A c...
#1Ying-Jia XuH-Index: 18
#2Ruo-Min DiH-Index: 1
Last.Yi-Qing YangH-Index: 25
view all 9 authors...
Abstract Congenital bicuspid aortic valve (BAV), the most common form of birth defect in humans, is associated with substantial morbidity and mortality. Increasing evidence demonstrates that genetic risk factors play a key role in the pathogenesis of BAV. However, BAV is a genetically heterogeneous disease and the genetic determinants underpinning BAV in an overwhelming majority of patients remain unknown. In the present study, the coding exons and flanking introns of the GATA6 gene, which encod...
#1Yu-Min Sun (Fudan University)H-Index: 7
#2Jun Wang (Fudan University)H-Index: 3
Last.Hong-Yu Shi (SJTU: Shanghai Jiao Tong University)H-Index: 6
view all 14 authors...
Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patients remains unclear. The present study was sought to investigate the association of a genetic variant in the ZBTB17 gene with DCM. A cohort of 158 unrelated patients with idiopathic D...
#1Xiao-Hui Qiao (Tongji University)H-Index: 2
#2Qian Wang (Tongji University)H-Index: 2
Last.Xin-Kai Qu (SJTU: Shanghai Jiao Tong University)H-Index: 16
view all 13 authors...
Abstract Congenital heart defect (CHD) is the most common type of birth defect in humans and a leading cause of infant morbidity and mortality. Previous studies have demonstrated that genetic defects play a pivotal role in the pathogenesis of CHD. However, the genetic basis of CHD remains poorly understood due to substantial genetic heterogeneity. In this study, the coding exons and splicing boundaries of the NR2F2 gene, which encodes a pleiotropic transcription factor required for normal cardio...
#1Ruo-Gu Li (SJTU: Shanghai Jiao Tong University)H-Index: 18
#2Ying-Jia Xu (Fudan University)H-Index: 2
Last.Yan-Jie Li (SJTU: Shanghai Jiao Tong University)H-Index: 4
view all 15 authors...
Aggregating evidence suggests that genetic determinants play a pivotal role in the pathogenesis of the congenitally bicuspid aortic valve (BAV). BAV is of pronounced genetic heterogeneity, and the genetic components underlying BAV in an overwhelming majority of patients remain elusive. In the current study, the whole coding exons and adjacent introns, as well as 5′ and 3′ untranslated regions of the GATA4 gene, which codes for a zinc-finger transcription factor crucial for the normal development...
#1Xing-Biao Qiu (SJTU: Shanghai Jiao Tong University)H-Index: 15
#2Xin-Kai Qu (SJTU: Shanghai Jiao Tong University)H-Index: 16
Last.Fang Yuan (SJTU: Shanghai Jiao Tong University)H-Index: 13
view all 15 authors...
Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patients remains unclear. The present study was sought to investigate the association of a genetic variant in the ZBTB17 gene with DCM. A cohort of 158 unrelated patients with idiopathic D...
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