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Jamadar Sharna
52Publications
13H-index
849Citations
Publications 52
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#1Jamadar Sharna (Monash University)H-Index: 13
#2Phillip G. D. Ward (Monash University)H-Index: 5
Last.Gary F. Egan (Monash University)H-Index: 64
view all 11 authors...
Functional positron emission tomography (fPET) provides a method to track molecular targets in the human brain. With a radioactively-labelled glucose analogue, 18F-fluordeoxyglucose (FDG-fPET), it is now possible to measure the dynamics of glucose metabolism with temporal resolutions approaching those of functional magnetic resonance imaging (fMRI). This direct measure of glucose uptake has enormous potential for understanding normal and abnormal brain function and probing the effects of metabol...
1 CitationsSource
#1Shenpeng Li (Monash University)H-Index: 4
#2Jamadar Sharna (Monash University)H-Index: 13
Last.Zhaolin Chen (Monash University)H-Index: 6
view all 6 authors...
Functional positron emission tomography (fPET) is a neuroimaging method involving continuous infusion of 18-F-fluorodeoxyglucose (FDG) radiotracer during the course of the PET examination. Compared with the conventional bolus administered static FDG PET which provides only a snapshot of the averaged glucose uptake into the brain in a limited dynamic time window, fPET offers a significantly wider time window to study the dynamics of glucose uptake. Several earlier studies have applied fPET to inv...
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#1Jamadar Sharna (Monash University, Clayton campus)H-Index: 13
#2Francesco Sforazzini (Monash University, Clayton campus)H-Index: 3
Last.Gary F. Egan (Monash University, Clayton campus)H-Index: 64
view all 14 authors...
5 CitationsSource
#1Jamadar Sharna (Monash University)H-Index: 13
#2Phillip G. D. Ward (Monash University)H-Index: 5
Last.Gary F. Egan (Monash University)H-Index: 64
view all 10 authors...
Functional Positron Emission Tomography (fPET) provides a method to track molecular dynamics in the human brain. With a radioactively labelled glucose-analogue, [18F]-flurodeoxyglucose (FDG-fPET), it is now possible to index the dynamics of glucose metabolism with temporal resolutions approaching those of functional magnetic resonance imaging (fMRI). This direct measure of glucose uptake has enormous potential for understanding normal and abnormal brain function, and probing the effects of metab...
1 CitationsSource
#1Jamadar SharnaH-Index: 13
Source
#1Jamadar Sharna (Monash University)H-Index: 13
#2Phillip G. D. Ward (Monash University)H-Index: 5
Last.Gary F. Egan (Monash University)H-Index: 64
view all 7 authors...
Abstract Studies of task-evoked brain activity are the cornerstone of cognitive neuroscience, and unravel the spatial and temporal brain dynamics of cognition in health and disease. Blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) is one of the most common methods of studying brain function in humans. BOLD-fMRI indirectly infers neuronal activity from regional changes in blood oxygenation and is not a quantitative metric of brain function. Regional variation in...
4 CitationsSource
#1Edwina Orchard (Monash University)H-Index: 1
#2Phillip G. D. Ward (Monash University)H-Index: 5
Last.Jamadar Sharna (Monash University)H-Index: 13
view all 6 authors...
Early parenthood results in changes in cortical thickness in regions related to parental care. However, the enduring effects of this period on the structure of the human brain, and cognition in late-life, is unknown. In an elderly sample, we examined the relationship between the number of children parented (here, 1-6 children) and cortical thickness in 267 males (74.0{+/-}3.5 years) and 231 females (73.8{+/-}3.5 years). We also compared cognition and cortical thickness between parents of one chi...
2 CitationsSource
#1Jamadar Sharna (Monash University)H-Index: 13
#2Beth Patricia Johnson (Monash University)H-Index: 11
The advent of functional magnetic resonance imaging (fMRI) in the early 1990s led to a rapid increase in the study of the neural bases of cognition. fMRI has made it possible to non-invasively study the spatial distribution of the neural processing of eye movements in humans, on a scale that was only previously achieved using invasive methods in animals and non-human primates. With increasing accessibility and affordability of fMRI, the field of functional neuroimaging has grown in usage, sophis...
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#1Maria V. Soloveva (Monash University)H-Index: 1
#2Jamadar Sharna (Monash University)H-Index: 13
Last.Nellie Georgiou-Karistianis (Monash University)H-Index: 34
view all 6 authors...
Abstract During premanifest stages of Huntington’s disease (pre-HD), individuals typically show increased functional brain activity thought to compensate for widespread brain anomalies. What remains unknown, is to disentangle whether increased functional brain activity reflects compensation or whether it is more of a product of HD-related pathological processes. We used a quantitative model of compensation, known as the CRUNCH (Compensation-Related Utilization of Neural Circuits Hypothesis) to c...
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#1Jakub Baran (Monash University)H-Index: 2
#2Zhaolin Chen (Monash University)H-Index: 6
Last.Gary F. Egan (Monash University)H-Index: 64
view all 10 authors...
Background Attenuation correction is one of the most crucial correction factors for accurate PET data quantitation in hybrid PET/MR scanners, and computing accurate attenuation coefficient maps from MR brain acquisitions is challenging. Here, we develop a method for accurate bone and air segmentation using MR ultrashort echo time (UTE) images.
2 CitationsSource
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