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Patrick Tobler
Boston Children's Hospital
2Publications
1H-index
4Citations
Publications 2
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Introduction: Quantitative magnetic resonance imaging (MRI) methods to quantify muscle tissue fat content are increasingly used in the evaluation of patients with inherited neuromuscular disorders. Recently, these techniques gained importance to detect disease progression and possible treatment responses. In this study, two widely used fat quantification MRI sequences (two- and three- point Dixon) were applied to assess the reproducibility and reliability of the techniques. Methods: For this cli...
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#1Simone Schmidt (University of Basel)H-Index: 2
#2Patricia Hafner (Boston Children's Hospital)H-Index: 10
Last.Ulrike Bonati (University of Basel)H-Index: 8
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The development of new therapeutic agents for the treatment of Duchenne muscular dystrophy has put a focus on defining outcome measures most sensitive to capture treatment effects. This cross-sectional analysis investigates the relation between validated clinical assessments such as the 6-minute walk test, motor function measure and quantitative muscle MRI of thigh muscles in ambulant Duchenne muscular dystrophy patients, aged 6.5 to 10.8 years (mean 8.2, SD 1.1). Quantitative muscle MRI include...
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