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Nadia R. P. W. Hutten
Maastricht University
PsychiatryPsychologyCognition4-FluoroamphetamineCannabis
13Publications
3H-index
23Citations
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Publications 17
Newest
#1Natasha L. Mason (UM: Maastricht University)H-Index: 3
#2K.P.C. Kuypers (UM: Maastricht University)H-Index: 1
Last. Amanda Feilding (Beckley Foundation)H-Index: 25
view all 11 authors...
There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions of the self-experience, like depression. Accumulating preclinical evidence emphasizes the role of the glutamate system in the acute action of the drug on brain and behavior; however this has never been tested in humans. Following a double-blind, placebo-controlled, parallel group design, we utilized an ultra-high field multimodal brain imaging approach and d...
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#1Natasha L. Mason (UM: Maastricht University)H-Index: 3
#2Eef L. Theunissen (UM: Maastricht University)H-Index: 21
Last. Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 8 authors...
Cannabis is the most commonly used illicit drug in the world. However, because of a changing legal landscape and rising interest in therapeutic utility, there is an increasing trend in (long-term) use and possibly cannabis impairment. Importantly, a growing body of evidence suggests that regular cannabis users develop tolerance to the impairing, as well as the rewarding, effects of the drug. However, the neuroadaptations that may underlie cannabis tolerance remain unclear. Therefore, this double...
1 CitationsSource
#1Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
#2Natasha L. Mason (UM: Maastricht University)H-Index: 3
Last. Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
view all 4 authors...
Background. There is a growing interest in the use of psychedelic substances for health related purposes, including symptom relief for disorders like anxiety, depression, and pain. Although the focus of recent clinical trials has been on high doses of these substances, anecdotal evidence suggests that low (micro) doses are also effective, and may be more suitable for certain conditions. Nonetheless, empirical evidence regarding the efficacy of microdosing with psychedelics for symptomatic relief...
3 CitationsSource
#1Natasha L. Mason (UM: Maastricht University)H-Index: 3
#2Eef L. Theunissen (UM: Maastricht University)H-Index: 21
Last. Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 8 authors...
Cannabis is the most commonly used illicit drug in the world. However due to a changing legal landscape, and rising interest in therapeutic utility, there is an increasing trend in (long-term) use and possibly, cannabis impairment. Importantly, a growing body of evidence suggests regular cannabis users develop tolerance to the impairing, as well as the rewarding, effects of the drug. However, the neuroadaptations that may underlie cannabis tolerance remain unclear. Therefore, this double-blind, ...
Source
#1Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
#2Natasha L. Mason (UM: Maastricht University)H-Index: 3
Last. Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
view all 4 authors...
Background: Microdosing with psychedelics has gained considerable media attention where it is portrayed as a performance enhancer, especially popular on the work floor. While reports are in general positive, scientific evidence about potential negative effects is lacking aside from the prevalence and motives for use. The present study addressed this gap by surveying psychedelic users about their experience with microdosing including their dosing schedule, motivation, and potential experienced ne...
3 CitationsSource
#1Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
#2Laura Steenbergen (LEI: Leiden University)H-Index: 10
Last. Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
view all 7 authors...
Abstract Anecdotal evidence suggests that cocaine use will help overcome creative ‘blocks’ by enhancing flexible thinking. Given that cocaine is likely to enhance dopamine (DA) levels, which in turn are positively associated with divergent thinking (DT); is a possibility that is tested in the present study. Furthermore, the impact of cocaine is tested on convergent thinking (CT), another aspect of creative thinking, which has been reported to be impaired with high DA levels. It was hypothesized ...
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#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
#2E. B. de Sousa Fernandes Perna (UM: Maastricht University)H-Index: 4
Last. Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 7 authors...
ABSTRACTThe phenethylamine 4-fluoroamphetamine (4-FA) is a so-called novel psychoactive substance with a chemical structure resembling that of amphetamine and MDMA. Since 4-FA users report their subjective experience ranges between the effects induced by amphetamine and MDMA, and it is known that both substances can produce an altered state of consciousness, this study tests whether 4-FA induces a psychedelic state. A placebo-controlled two-way crossover study in 12 healthy poly-drug users was c...
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#1Eef L. Theunissen (UM: Maastricht University)H-Index: 21
#2Nadia R. P. W. Hutten (UM: Maastricht University)H-Index: 3
Last. Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 6 authors...
Abstract Introduction: Synthetic cannabinoid mixtures have been easily accessible for years, leading to the belief that these products were natural and harmless, which contributed to their populari...
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