Frank M. Lehmann
University of Basel
Interleukin 3Interleukin 12GranzymeInnate lymphoid cellBiology
What is this?
Publications 2
#1Ana Raykova (UZH: University of Zurich)H-Index: 7
#2Paolo Carrega (UNIME: University of Messina)H-Index: 16
Last. Christian Münz (UZH: University of Zurich)H-Index: 64
view all 11 authors...
Type 3 innate lymphoid cells (ILC3s) fulfill protective functions at mucosal surfaces via cytokine production. Although their plasticity to become ILC1s, the innate counterparts of type 1 helper T cells, has been described previously, we report that they can differentiate into cytotoxic lymphocytes with many characteristics of early differentiated natural killer (NK) cells. This transition is promoted by the proinflammatory cytokines interleukin 12 (IL-12) and IL-15, and correlates with expressi...
7 CitationsSource
#1Elise Dalmas (University of Basel)H-Index: 8
#2Frank M. Lehmann (University of Basel)H-Index: 2
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 21 authors...
Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
28 CitationsSource