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Amir Zeb
Gyeongsang National University
24Publications
5H-index
64Citations
Publications 24
Newest
#1Raees Khan (Dong-a University)H-Index: 4
#2Amir Zeb (Gyeongsang National University)H-Index: 5
Last.Seon-Woo Lee (Dong-a University)H-Index: 12
view all 6 authors...
Enoyl-acyl carrier protein reductase (ENR) catalyzes the last reduction step in the bacterial type II fatty acid biosynthesis cycle. ENRs include FabI, FabL, FabL2, FabK, and FabV. Previously, we reported a unique triclosan (TCL) resistant ENR homolog that was predominant in obligate intracellular pathogenic bacteria and Apicomplexa. Herein, we report the biochemical and structural basis of TCL resistance in this novel ENR. The purified protein revealed NADH-dependent ENR activity and shared sim...
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#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Ayoung Baek (Gyeongsang National University)H-Index: 7
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 11 authors...
Aromatase inhibitors with an \mathrm{IC}_{50}IC 50 value ranging from 1.4 to 49.7 µM are known to act as antiepileptic drugs besides being potential breast cancer inhibitors. The aim of the present study is to identify novel antiepileptic aromatase inhibitors with higher activity exploiting the ligand-based pharmacophore approach utilizing the experimentally known inhibitors. The resultant Hypo1 consists of four features and was further validated by using three different strategies. Hypo1 was...
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#1Amir ZebH-Index: 5
#2Donghwan KimH-Index: 1
Last.Keun Woo LeeH-Index: 30
view all 12 authors...
Mechanistically, neurotoxic insults provoke Ca2+-mediated calpain activation, which cleaves the cytoplasmic region of membrane-embedded p35 and produces its truncated form p25. Upon physical interaction, cyclin-dependent kinase 5 (Cdk5) and p25 forms hyperactivated Cdk5/p25 complex and causes severe neuropathological aberrations including hyperphosphorylated tau-mediated neurofibrillary tangles formation, Alzheimer’s symptoms, and neuronal death. Therefore, the inhibition of Cdk5/p25 complex may...
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#1Raj Kumar (Gyeongsang National University)H-Index: 5
#2Saravanan Parameswaran (Gyeongsang National University)H-Index: 1
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 12 authors...
Abstract Prolyl oligopeptidase (POP) is a potential therapeutic target for treatment of several neurological disorders and α-synucleinopathies including Parkinson's disease. Most of the known POP inhibitors failed in the clinical trials due to poor pharmacokinetic properties and blood-brain impermeability. Therefore, a training set of 30 structurally diverse compounds with a wide range of inhibitory activity against POP was used to generate a quantitative pharmacophore model, Hypo 3, to identify...
1 CitationsSource
#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Chanin Park (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 14 authors...
Breast cancer (BC) is the leading cause of death among women worldwide devoid of effective treatment. It is therefore important to develop agents that can reverse, reduce, or slow the growth of BC. The use of natural products as chemopreventive agents provides enormous advantages. The aim of the current investigation is to determine the efficacy of the phytochemicals against BC along with the approved drugs to screen the most desirable and effective phytocompound. In the current study, 36 phytoc...
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#1Shahab Uddin (University of Malakand)H-Index: 1
#2Imdad Ali (University of Malakand)
Last.Ayaz Ali Khan (University of Malakand)H-Index: 4
view all 11 authors...
Diabetes mellitus (DM) is an epidemic disease and causes severe problem to human health [1].
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#1Shafiq Ur Rehman (Gyeongsang National University)H-Index: 11
#2Tahir Ali (Gyeongsang National University)H-Index: 14
Last.Myeong Ok Kim (Gyeongsang National University)H-Index: 29
view all 8 authors...
Microglia play a crucial role in the inflammatory brain response to infection. However, overactivation of microglia is neurotoxic. Toll-like receptor 4 (TLR4) is involved in microglial activation via lipopolysaccharide (LPS), which triggers a variety of cytotoxic pro-inflammatory markers that produce deleterious effects on neuronal cells. Ferulic acid (FA) is a phenolic compound that exerts antioxidant and anti-inflammatory effects in neurodegenerative disease. However, the manner in which FA in...
14 CitationsSource
#1Amir Zeb (Gyeongsang National University)H-Index: 5
#2Chanin Park (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 6 authors...
Protein acetylation and deacetylation play vital roles in the structural and physiological behavior of target proteins. Histone deacetylase 6 (HDAC6) remains a key therapeutic target in several chronic diseases such as cancer, neurodegenerative, and hematological diseases. In tau-pathogenesis, HDAC6 tightly regulates microtubule-associated tau physiology, and its inhibition suppresses Alzheimer’s phenotype. To this end, the current study has identified novel HDAC6 inhibitors by structure-based d...
3 CitationsSource
Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Deficits in cholinergic neurotransmitters are linked closely with the progression of Alzheimer’s disease (AD), which is a neurodegenerative disorder characterized by memory impairment, and a disordered cognitive function. Since the previously approved AChE inhibitors, donepezil (Aricept), galantamine (Reminyl), and rivastigmine (Exelon), have side effects and several...
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#1Rabia Mukhtar RanaH-Index: 1
#2Shailima RampoguH-Index: 7
Last.Keun Woo LeeH-Index: 30
view all 11 authors...
Dihydrofolate reductase (DHFR) is an essential cellular enzyme and thereby catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). In cancer medication, inhibition of human DHFR (hDHFR) remains a promising strategy, as it depletes THF and slows DNA synthesis and cell proliferation. In the current study, ligand-based pharmacophore modeling identified and evaluated the critical chemical features of hDHFR inhibitors. A pharmacophore model (Hypo1) was generated from known inhibitors of D...
1 CitationsSource
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