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Krishna D.B. Anapindi
University of Illinois at Urbana–Champaign
4Publications
2H-index
9Citations
Publications 4
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#1Krishna D.B. Anapindi (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
#2Elena Vikentievna Romanova (UIUC: University of Illinois at Urbana–Champaign)H-Index: 22
Last.Jonathan V. Sweedler (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
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Abstract Characterization of endogenous neuropeptides produced from post-translational proteolytic processing of precursor proteins is a demanding task. A variety of complex prohormone processing steps generate molecular diversity from neuropeptide prohormones, making in silico neuropeptide discovery difficult. In addition, the wide range of endogenous peptide concentrations as well as significant peptide complexity further challenge the structural characterization of neuropeptides. Liquid chrom...
4 CitationsSource
#1Ning Yang (UIUC: University of Illinois at Urbana–Champaign)H-Index: 3
#2Krishna D.B. Anapindi (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last.Jonathan V. SweedlerH-Index: 68
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Conserved across vertebrates, the habenular nuclei are a pair of small symmetrical structures in the epithalamus. The nuclei functionally link the forebrain and midbrain by receiving input from and projecting to several brain regions. Each habenular nucleus comprises two major asymmetrical subnuclei, the medial and lateral habenula. These subnuclei are associated with different physiological processes and disorders, such as depression, nicotine addiction, and encoding aversive stimuli or omittin...
2 CitationsSource
#1Ning Yang (UIUC: University of Illinois at Urbana–Champaign)H-Index: 3
#2Krishna D.B. Anapindi (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last.Jonathan V. Sweedler (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
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Measurement, identification, and quantitation of endogenous peptides in tissue samples by mass spectrometry (MS) contribute to our understanding of the complex molecular mechanisms of numerous biological phenomena. For accurate results, it is essential to arrest the postmortem degradation of ubiquitous proteins in samples prior to performing peptidomic measurements. Doing so ensures that the detection of endogenous peptides, typically present at relatively low levels of abundance, is not overwhe...
3 CitationsSource
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