Deok gyun You
Korea University
Bcl-2 familyHepatitis C virusMitochondrionHBxBiology
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Publications 3
#1Hye Ra Lee (KU: Korea University)H-Index: 3
#1Hye-Ra LeeH-Index: 18
Last. Youngil Koh (KU: Korea University)H-Index: 43
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Hepatitis C virus (HCV) p7 is known to be a nonselective cation channel for HCV maturation. Because the interaction of HCV proteins with host lipids in the endoplasmic reticulum membrane is crucial for the budding process, the identification of p7–lipid interactions could be important for understanding the HCV life cycle. Here, we report that p7 interacts with phosphatidylserine (PS) to induce membrane permeabilization. The interaction of p7 with PS was not inhibited by Gd3+ ions, which have bee...
#1Deok gyun You (KU: Korea University)H-Index: 1
#2Young Youn Cho (SNU: Seoul National University)H-Index: 11
Last. Gi Young Lee (KU: Korea University)H-Index: 4
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Abstract Hepatitis B virus X protein (HBx) functions in a variety of cellular events during the HBV life cycle. In a previous study, we reported that the HBx protein is sufficient to induce mitochondrial membrane permeabilization; however, the exact mechanism of HBx-induced mitochondrial membrane permeabilization has been not proposed. In this study, we report that HBx specifically targets cardiolipin (CL) and induces membrane permeabilization depending on CL concentration in mitochondrial outer...
2 CitationsSource
#1Deok gyun You (KU: Korea University)H-Index: 1
#2Hye Ra Lee (KU: Korea University)H-Index: 3
Last. Youngil Koh (KU: Korea University)H-Index: 43
view all 6 authors...
: Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the function of HCV p7 in mitochondria is not fully understood. The present study demonstrated that treatment of isolated mouse liver mitochondria with the synthesized HCV p7 protein ind...