Wen Shang Saw
University of Malaya
CopolymerOrganic chemistryPhotothermal therapyChemistryDoxorubicin
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Publications 5
#1Yiing Yee Foo (UM: University of Malaya)H-Index: 1
#2Wen Shang Saw (UM: University of Malaya)
Last. Saad Tayyab (UM: University of Malaya)H-Index: 20
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In this work, the use of gold nanoparticles (AuNPs), synthesised using Curcuma mangga (CM) extract in photothermal killing of breast cancer (MCF-7) cells is demonstrated. CM-AuNPs showed higher photothermal heating efficiency compared to citrate-AuNPs upon irradiation with a 532 nm laser. In addition, treatment of MCF-7 cells with CM-AuNPs coupled with laser irradiation for 120 s was found to significantly reduce (72%) the cell viability compared to about 13%, obtained with citrate-AuNPs. Result...
#1Laura Chambre (Boğaziçi University)H-Index: 2
#2Wen Shang SawH-Index: 3
Last. Amitav Sanyal (Boğaziçi University)H-Index: 25
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Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photoinduced killing efficiency was tested against three cell lines: human breast adenocarcino...
1 CitationsSource
#1Wen Shang Saw (UM: University of Malaya)H-Index: 3
#2Masaki Ujihara (NTUST: National Taiwan University of Science and Technology)H-Index: 8
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract Physiochemical changes, including size, are known to affect gold nanoparticle cellular internalization and treatment efficacy. Here, we report the effect of four sizes of cystine/citric acid-coated confeito-like gold nanoparticles (confeito-AuNPs) (30, 60, 80 and 100 nm) on cellular uptake, intracellular localization and photothermal anticancer treatment efficiency in MDA-MB231 breast cancer cells. Cellular uptake is size dependent with the smallest size of confeito-AuNPs (30 nm) having...
11 CitationsSource
#1Siew Hui Voon (UM: University of Malaya)H-Index: 6
#2Chin Siang Kue (UM: University of Malaya)H-Index: 4
Last. Shin-ichi Yusa (University of Hyogo)H-Index: 29
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Abstract Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing m...
3 CitationsSource
#1Yu-Hsuan Hsu (NTUST: National Taiwan University of Science and Technology)H-Index: 2
#2Hui-Ling Hsieh (NTUST: National Taiwan University of Science and Technology)H-Index: 1
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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We functionalized graphene oxide (GO) with cyclodextrin (CD) to increase the drug loading and cellular uptake of GO, and bound the GO-CD to carbon-coated iron nanoparticles (Fe@C) with superparamagnetic properties for potential magnetic-directed drug delivery and as a diagnostic agent. The GO-CD/Fe@C was loaded with an anticancer drug, doxorubicin (DOX), to form a multifunctional GO-CD/Fe@C/DOX nanohybrid. A cumulative increase in DOX loading was observed probably due to DOX adsorption to the gr...
3 CitationsSource