Xavier Heiligenstein
PSL Research University
Publications 17
#1Eric Peterman (Anschutz Medical Campus)H-Index: 2
#2Paulius Gibieža (Lithuanian University of Health Sciences)H-Index: 2
Last.Rytis Prekeris (Anschutz Medical Campus)H-Index: 42
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Once thought to be a remnant of cell division, the midbody (MB) has recently been shown to have roles beyond its primary function of orchestrating abscission. Despite the emerging roles of post-abscission MBs, how MBs accumulate in the cytoplasm and signal to regulate cellular functions remains unknown. Here, we show that extracellular post-abscission MBs can be internalized by interphase cells, where they reside in the cytoplasm as a membrane-bound signaling structure that we have named the MBs...
2 CitationsSource
#1Christin BissigH-Index: 3
#2Pauline CroiséH-Index: 1
Last.Guillaume van NielH-Index: 25
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There was an error in J. Cell Sci. (2019) 132, [jcs229500][1] ([doi:10.1242/jcs.229500][2]). The DMSO lanes in [Fig. 2][3]C and D were duplicated in [Fig. 2][3]E and F, respectively, which contravenes our image presentation guidelines. The authors supplied full blots for all these panels and
#1Christin Bissig (CNRS: Centre national de la recherche scientifique)H-Index: 3
#2Pauline Croisé (Paris V: Paris Descartes University)H-Index: 1
Last.Guillaume van Niel (Paris V: Paris Descartes University)H-Index: 25
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ABSTRACT The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show that PIKfyve activity regulates formation of amyloid matrix composed of PMEL protein within the early endosomes in melanocytes, called stage I melanosomes. PIKfyve activity controls the membr...
5 CitationsSource
#1Léa Ripoll (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Xavier Heiligenstein (CNRS: Centre national de la recherche scientifique)H-Index: 5
Last.Cédric Delevoye (CNRS: Centre national de la recherche scientifique)H-Index: 17
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Vesicular and tubular transport intermediates regulate organellar cargo dynamics. Transport carrier release involves local and profound membrane remodeling before fission. Pinching the neck of a budding tubule or vesicle requires mechanical forces, likely exerted by the action of molecular motors on the cytoskeleton. Here, we show that myosin VI, together with branched actin filaments, constricts the membrane of tubular carriers that are then released from melanosomes, the pigment containing lys...
10 CitationsSource
#1Bertha Mayela Toledo Acosta (IRIA: French Institute for Research in Computer Science and Automation)H-Index: 1
#2Xavier Heiligenstein (PSL Research University)H-Index: 5
Last.Patrick Bouthemy (IRIA: French Institute for Research in Computer Science and Automation)H-Index: 37
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Correlative microscopy, especially light and electron microscopy (CLEM), enables the study of cells and subcellular elements in complementary ways, provided a reliable registration between images is efficiently achievable. We propose a general automatic registration method. Due to large discrepancies in appearance, field-of-view, resolution and position, a pre-alignment stage is required before any 3D fine registration stage. We define an intensity-based method for both stages, which leverages a...
Last.Jean SalameroH-Index: 35
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#1Perrine Paul-Gilloteaux (University of Nantes)H-Index: 16
#2Xavier Heiligenstein (PSL Research University)H-Index: 5
Last.Jean Salamero (PSL Research University)H-Index: 35
view all 8 authors...
54 CitationsSource