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Yongfeng Yang
Peking University
DNA repairDNA damageMolecular biologyPoly ADP ribose polymeraseCancer research
3Publications
2H-index
11Citations
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Publications 4
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#1Yongfeng Yang (PKU: Peking University)H-Index: 2
#2Chuanzhen Yang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 8 authors...
The DNA damage response (DDR) is essential for maintaining genome integrity. Mounting evidence reveals that protein modifications play vital roles in the DDR. Here, we show that USP38 is involved in the DDR by regulating the activity of HDAC1. In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63-linked ubiquitin chain promoting the deacetylase activity of HDAC1. As a result, HDAC1 was able to deacetylate H3K56. USP38 deletion resulted in persistent focal accumu...
Source
#1Chuanzhen Yang (PKU: Peking University)H-Index: 2
#2Weicheng Zang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 6 authors...
2 CitationsSource
#1Chuanzhen Yang (PKU: Peking University)H-Index: 2
#2Weicheng Zang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 11 authors...
A competent DNA damage response (DDR) helps prevent cancer, but once cancer has arisen DDR can blunt the efficacy of chemotherapy and radiotherapy which cause lethal DNA breakage in cancer cells. Thus, blocking DDR may improve the efficacy of these modalities. Here we report a new DDR mechanism that interfaces with inflammatory signaling and might be blocked to improve anticancer outcomes. Specifically, we report that the ubiquitin-editing enzyme A20 binds and inhibits the E3 ubiquitin ligase RN...
5 CitationsSource
#1Yapeng Ji (PKU: Peking University)H-Index: 3
#2Chuanzhen Yang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 19
view all 10 authors...
Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
4 CitationsSource
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