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Sarah Levesque
Pierre-and-Marie-Curie University
11Publications
4H-index
146Citations
Publications 11
Newest
Published on Apr 2, 2019in Nature Communications 12.35
Peng Liu38
Estimated H-index: 38
,
Liwei Zhao4
Estimated H-index: 4
+ 31 AuthorsKristina Iribarren8
Estimated H-index: 8
Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulates antitumor immune responses. Here we unravel the results of an unbiased screen identifying high-dose (10 µM) crizotinib as an ICD-inducing tyrosine kinase inhibitor that has exceptional antineoplastic activity when combined with non-ICD inducing chemotherapeutics like cisplatin. The combination of cisplatin and high-dose crizotinib induces ICD in non-small cell lung carcinoma (NSCLC) cells and effec...
2 Citations Source Cite
Published on Apr 17, 2019in Nature Communications 12.35
Peng Liu38
Estimated H-index: 38
,
Liwei Zhao4
Estimated H-index: 4
+ 31 AuthorsKristina Iribarren8
Estimated H-index: 8
The original version of this Article contained an error in the spelling of the author Lin Xia, which was incorrectly given as Xia Lin. This has now been corrected in both the PDF and HTML versions of the Article.
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Published on Jul 3, 2019in OncoImmunology 5.50
Wei Xie1
Estimated H-index: 1
,
Laura Mondragón18
Estimated H-index: 18
+ 11 AuthorsLaurence Zitvogel72
Estimated H-index: 72
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Published on Jul 3, 2019in OncoImmunology 5.50
Sarah Levesque4
Estimated H-index: 4
,
Jonathan Pol14
Estimated H-index: 14
+ 3 AuthorsGuido Kroemer191
Estimated H-index: 191
(UPMC: Pierre-and-Marie-Curie University)
ABSTRACTDietary interventions have a profound impact on whole body metabolism, including oncometabolism (the metabolic features allowing cancer cells to proliferate) and immunometabolism (the catabolic and anabolic reactions that regulate immune responses). Recent preclinical studies demonstrated that multiple dietary changes can improve anticancer immunosurveillance of chemo-, radio- and immunotherapy. These findings have fostered the design of clinical trials evaluating the capacity of dietary...
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Published on Mar 4, 2019in OncoImmunology 5.50
Kristina Iribarren8
Estimated H-index: 8
(University of Paris-Sud),
Aitziber Buqué14
Estimated H-index: 14
(University of Paris-Sud)
+ 6 AuthorsGuido Kroemer191
Estimated H-index: 191
(UPMC: Pierre-and-Marie-Curie University)
ABSTRACTThe treatment of breast cancer largely depends on the utilization of immunogenic chemotherapeutics, which, as a common leitmotif, stimulate the exposure of calreticulin (CALR) on the surface of cancer cells, thereby facilitating their recognition by dendritic cells for the uptake of tumor-associated antigens and subsequent antigen cross-presentation to cytotoxic T cells. Breast cancer cells also express the calreticulin antagonist CD47, which inhibits tumor cell phagocytosis and conseque...
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Published on Jan 1, 2019
Juliette Humeau6
Estimated H-index: 6
,
Sarah Levesque4
Estimated H-index: 4
+ 1 AuthorsJonathan Pol14
Estimated H-index: 14
2 Citations Source Cite
Published on Dec 2, 2018in OncoImmunology 5.50
Jonathan Pol14
Estimated H-index: 14
(UPMC: Pierre-and-Marie-Curie University),
Sarah Levesque4
Estimated H-index: 4
(UPMC: Pierre-and-Marie-Curie University)
+ 12 AuthorsKaren L. Mossman42
Estimated H-index: 42
(McMaster University)
ABSTRACTOncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic herpes simplex virus T-VEC for use in advanced melanoma patients. Since then, a plethora of trials has been initiated to assess the safety and efficacy of multiple oncolytic viruses in patients affected with various malignancies. Here, w...
2 Citations Source Cite
Published on Jul 13, 2018in The EMBO Journal 10.56
Florine Obrist9
Estimated H-index: 9
,
Judith Michels15
Estimated H-index: 15
+ 9 AuthorsGen Sheng Wu10
Estimated H-index: 10
(WSU: Wayne State University)
Abstract Cisplatin is the most widely used chemotherapeutic agent, and resistance of neoplastic cells against this cytoxicant poses a major problem in clinical oncology. Here, we explored potential metabolic vulnerabilities of cisplatin‐resistant non‐small human cell lung cancer and ovarian cancer cell lines. Cisplatin‐resistant clones were more sensitive to killing by nutrient deprivation in vitro and in vivo than their parental cisplatin‐sensitive controls. The susceptibility of cisplatin‐resi...
5 Citations Source Cite
Published on Mar 4, 2017in Autophagy 11.10
Federico Pietrocola22
Estimated H-index: 22
(UPMC: Pierre-and-Marie-Curie University),
Yohann Demont7
Estimated H-index: 7
(UPMC: Pierre-and-Marie-Curie University)
+ 14 AuthorsChloé Bordenave2
Estimated H-index: 2
(French Institute of Health and Medical Research)
ABSTRACTStarvation is a strong physiological stimulus of macroautophagy/autophagy. In this study, we addressed the question as to whether it would be possible to measure autophagy in blood cells after nutrient deprivation. Fasting of mice for 48 h (which causes ∼20% weight loss) or starvation of human volunteers for up to 4 d (which causes <2% weight loss) provokes major changes in the plasma metabolome, yet induces only relatively minor alterations in the intracellular metabolome of circulating...
14 Citations Source Cite
Published on Oct 2, 2016in Autophagy 11.10
Federico Pietrocola22
Estimated H-index: 22
(Paris V: Paris Descartes University),
Jonathan Pol14
Estimated H-index: 14
(Paris V: Paris Descartes University)
+ 6 AuthorsGuido Kroemer191
Estimated H-index: 191
(Karolinska University Hospital)
ABSTRACTCancer can be viewed in 2 rather distinct ways, namely (i) as a cell-autonomous disease in which malignant cells have escaped control from cell-intrinsic barriers against proliferation and dissemination or (ii) as a systemic disease that involves failing immune control of aberrant cells. Since macroautophagy/autophagy generally increases the fitness of cells as well as their resistance against endogenous or iatrogenic (i.e., relating to illness due to medical intervention) stress, it has...
16 Citations Source Cite
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