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Véronique Capuano
French Institute of Health and Medical Research
7Publications
2H-index
88Citations
Publications 7
Newest
Published on 2019in Circulation Research15.86
Mélanie Lambert4
Estimated H-index: 4
(French Institute of Health and Medical Research),
Véronique Capuano2
Estimated H-index: 2
+ 7 AuthorsAurélie Hautefort7
Estimated H-index: 7
(French Institute of Health and Medical Research)
Rationale: Pulmonary arterial hypertension (PAH) is a severe lethal cardio-pulmonary disease. Loss of function mutations in KCNK3 gene, which encodes an outward rectifier K+ channel, have been iden...
Published on Jun 1, 2019in Journal of Heart and Lung Transplantation8.58
Jennifer Arthur Ataam (Stanford University), Olaf Mercier (French Institute of Health and Medical Research)+ 10 AuthorsMaria-Rosa Ghigna7
Estimated H-index: 7
(French Institute of Health and Medical Research)
ABSTRACT BACKGROUND- Pulmonary endothelial cells play a key role in the pathogenesis of Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Increased synthesis and/or release of Intercellular Adhesion Molecule 1 (ICAM-1) by pulmonary endothelial cells of patients with CTEPH has been recently reported, suggesting a potential role for ICAM-1 in CTEPH. METHODS- We studied pulmonary endarterectomy specimens from 172 patients with CTEPH and pulmonary artery specimens from 97 controls undergoing lo...
Published on Oct 14, 2018in International Journal of Molecular Sciences4.18
Mélanie Lambert4
Estimated H-index: 4
,
Véronique Capuano2
Estimated H-index: 2
+ 6 AuthorsFabrice Antigny21
Estimated H-index: 21
Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K+, Ca2+, Na+ and Cl−). This review focuses on ion channels in the pulmonary vasculature and discusses their pathophysiological contribution to PAH as well as their therapeutic potential in PAH.
Published on Sep 15, 2018in European Respiratory Journal11.81
Mélanie Lambert4
Estimated H-index: 4
,
Véronique Capuano2
Estimated H-index: 2
+ 7 AuthorsFabrice Antigny21
Estimated H-index: 21
Published on May 1, 2018in Cardiovascular Research7.01
Mélanie Lambert4
Estimated H-index: 4
(French Institute of Health and Medical Research),
Angèle Boet3
Estimated H-index: 3
+ 16 AuthorsAurélie Hautefort7
Estimated H-index: 7
(French Institute of Health and Medical Research)
Published on Oct 1, 2017in Biochimica et Biophysica Acta3.79
Safietou Sankhe1
Estimated H-index: 1
(French Institute of Health and Medical Research),
Sevasti Manousakidi1
Estimated H-index: 1
(French Institute of Health and Medical Research)
+ 12 AuthorsElie Fadel50
Estimated H-index: 50
(French Institute of Health and Medical Research)
Abstract Idiopathic pulmonary arterial hypertension (iPAH) is characterized by obstructive hyperproliferation and apoptosis resistance of distal pulmonary artery smooth muscle cells (PASMCs). T-type Ca 2 + channel blockers have been shown to reduce experimental pulmonary hypertension, although the impact of T-type channel inhibition remains unexplored in PASMCs from iPAH patients. Here we show that T-type channels Cav3.1 and Cav3.2 are present in the lung and PASMCs from iPAH patients and contro...
Published on Jan 1, 2012
Yann Ruchon2
Estimated H-index: 2
,
Laurent Ferron11
Estimated H-index: 11
+ 1 AuthorsVéronique Capuano2
Estimated H-index: 2
Published on Dec 12, 2003in Circulation Research15.86
Laurent Ferron11
Estimated H-index: 11
,
Véronique Capuano2
Estimated H-index: 2
+ 3 AuthorsJean-François Renaud11
Estimated H-index: 11
Recent studies indicate that cardiac T-type Ca 2+ current ( I CaT ) reappears in hypertrophied ventricular cells. The aim of this study was to investigate the role of angiotensin II (Ang II), a major inducer of cardiac hypertrophy, in the reexpression of T-type channel in left ventricular hypertrophied myocytes. We induced cardiac hypertrophy in rats by abdominal aorta stenosis for 12 weeks and thereafter animals were treated for 2 weeks with losartan (12 mg/kg per day), an antagonist of type 1 ...
Published on Dec 12, 2003in Circulation Research15.86
Laurent Ferron11
Estimated H-index: 11
,
Véronique Capuano2
Estimated H-index: 2
+ 3 AuthorsJean-FrançoisRenaud
Recent studies indicate that cardiac T-type Ca2+ current (ICaT) reappears in hypertrophied ventricular cells. The aim of this study was to investigate the role of angiotensin II (Ang II), a major inducer of cardiac hypertrophy, in the reexpression of T-type channel in left ventricular hypertrophied myocytes. We induced cardiac hypertrophy in rats by abdominal aorta stenosis for 12 weeks and thereafter animals were treated for 2 weeks with losartan (12 mg/kg per day), an antagonist of type 1 Ang ...
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