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Alfredo Lucas
University of California, San Diego
4Publications
Publications 4
Newest
Published on Apr 5, 2019in Journal of Proteome Research 3.95
Sarah Gehrke3
Estimated H-index: 3
(University of Colorado Denver),
Sarah Rice1
Estimated H-index: 1
(UAF: University of Alaska Fairbanks)
+ 8 AuthorsKelly L. Drew29
Estimated H-index: 29
(UAF: University of Alaska Fairbanks)
Arctic ground squirrels provide a unique model to investigate metabolic responses to hibernation in mammals. During winter months these rodents are exposed to severe hypothermia, prolonged fasting, and hypoxemia. In the light of their role in oxygen transport/off-loading and owing to the absence of nuclei and organelles (and thus de novo protein synthesis capacity), mature red blood cells have evolved metabolic programs to counteract physiological or pathological hypoxemia. However, red blood ce...
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Published on Jan 1, 2019in Drug Delivery 3.10
Alfredo Lucas (UCSD: University of California, San Diego), Dawn Lam (UCSD: University of California, San Diego), Pedro Cabrales35
Estimated H-index: 35
(UCSD: University of California, San Diego)
AbstractDoxorubicin (DOX) is one of the most widely used anticancer agents. DOX is known for inducing cardiotoxicity, resulting in the long-term development of heart failure. Intravascular delivery of DOX may benefit from the carriage by red blood cells (RBCs), as they can limit the systemic toxicity while delivering the DOX to the tumor. This study proposes a methodology for the synthesis of electrophoretically DOX-loaded red blood cells (RBC-DOX), as well as the assessment of its antitumorigen...
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Alfredo Lucas (UCSD: University of California, San Diego), John Hermiz3
Estimated H-index: 3
(UCSD: University of California, San Diego)
+ 3 AuthorsVikash Gilja21
Estimated H-index: 21
(UCSD: University of California, San Diego)
Stroke patients are monitored hourly by physicians and nurses in an attempt to better understand their physical state. To quantify the patients’ level of mobility, hourly movement (i.e. motor) assessment scores are performed, which can be taxing and time consuming for nurses and physicians. In this study we attempt to find a correlation between patient motor scores and continuous accelerometer data recorded in subjects who are unilaterally impaired due to stroke. The accelerometers were placed o...
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Vivek P. Jani2
Estimated H-index: 2
(UCSD: University of California, San Diego),
Shawn Mailo (UCSD: University of California, San Diego)+ 3 AuthorsPedro Cabrales35
Estimated H-index: 35
(UCSD: University of California, San Diego)
In 2013, nearly 15 million units of banked blood were transfused in the United States of America alone. Blood shortages are expected to increase globally. Donated blood is not equal due to differences in quality and deterioration rate. There are no methods to detect time-dependent biochemical and biophysical changes of red blood cells (RBCs) or the deterioration rate of donated RBCs. Nine randomly selected RBC units collected by the San Diego Blood Bank were examined for interdonor variability o...
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