Yuki Marumo
University of Toyama
ChemistryMagnesium stearateMicrocrystalline celluloseChromatographyActive ingredient
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Publications 3
#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Yuki Marumo (University of Toyama)H-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
Abstract The purpose of this study was to explore the potential of a quantitative structure–property relationship (QSPR) model to predict tablet density. First, we calculated 3381 molecular descriptors for 81 active pharmaceutical ingredients (API). Second, we obtained data that were merged with a dataset including powder properties that we had constructed previously. Next, we prepared 81 types of tablet, each containing API, microcrystalline cellulose, and magnesium stearate using direct compre...
#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Takuya Oishi (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
AbstractObjectives: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a tensile strength (TS) of tablets as critical quality attributes.Methods: First, we evaluated 81 kinds of API characteristics, such as particle size distribution, bulk density, tapped density, Hausner ratio, moisture content, elastic recovery, molecular weight, and partition coefficient. Next, we prepared ta...
4 CitationsSource
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Atsushi KosugiH-Index: 2
Last. Yoshihiro Hayashi (University of Toyama)H-Index: 7
view all 8 authors...
Abstract To gain a better understanding of disintegration actions, 11 different disintegrants were tested. Model tablets were prepared with various preparation conditions, and their disintegration time and tensile strength were measured. The present study also investigated various physicochemical properties of the model tablets and disintegrant powders, including wetting time, water absorption ratio, particle size, morphological observation, swelling property, and T 2 relaxation time ( T 2 ). Th...
4 CitationsSource