Match!
Anna Karagianni
Aristotle University of Thessaloniki
MiscibilityChemistryDifferential scanning calorimetryChromatographyAmorphous solid
8Publications
3H-index
25Citations
What is this?
Publications 9
Newest
#1Konstantinos Katopodis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
#2Afroditi Kapourani (A.U.Th.: Aristotle University of Thessaloniki)
Last. Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
view all 9 authors...
Abstract The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes. Specifically, the effect of mannitol (MAN), sorbitol (SOR), sucrose (SUC), anhydrous citric acid (CA), triethyl citrate (TEC) and low-molecular weight polyethylene glycol (PEG400) on PVA’s melting properties, physical state and thermal degradation wa...
Source
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 5 authors...
Abstract A realistic molecular description of amorphous drug-polymer-plasticizer matrices, suitable for the preparation of amorphous solid dispersions (ASDs) with the aid of fusion-based techniques, was evaluated. Specifically, the incorporation of two model drugs (i.e. ibuprofen, IBU, and carbamazepine, CBZ) having substantially different thermal properties and glass forming ability, on the molecular representation of polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer (...
2 CitationsSource
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 4 authors...
Abstract In the present study, the preparation of pharmaceutical mini-tablets was attempted in the framework of Quality by Design (QbD) context, by comparing traditionally used multi-linear regression (MLR), with artificially-intelligence based regression techniques (such as standard artificial neural networks (ANNs), particle swarm optimization (PSO) ANNs and genetic programming (GP)) during Design of Experiment (DoE) implementation. Specifically, the effect of diluent type and particle size fr...
Source
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 4 authors...
Abstract The aim of the present study was to evaluate the thermodynamic properties of in-situ formation of cocrystal formulations by the melt-mixing method. Specifically, the thermodynamic mixing behaviour of carbamazepine-nicotinamide and ibuprofen-nicotinamide cocrystals prepared with the aid of Soluplus® (SOL) were evaluated using thermodynamic lattice-based solution theories. Thermodynamic miscibility of both cocrystals with SOL was predicted by calculating Gibb′s free energy based on the Fl...
Source
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 4
view all 4 authors...
Abstract The present work describes the development of an efficient, fast and accurate method for the quantification of polymer-based cocrystal formulations. Specifically, the content of carbamazepine–nicotinamide (CBZ/NIC) and ibuprofen-nicotinamide (IBU/NIC) cocrystals in Soluplus®-based formulations was independently determined with the aid of either Raman or Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy (ATR-FTIR) spectroscopy. Spectra peaks from mixtures of IBU/NIC an...
3 CitationsSource
#1Anna KaragianniH-Index: 3
Last. Ioannis NikolakakisH-Index: 14
view all 3 authors...
The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this reason, the production of amorphous drugs with adequate stability remains a major challenge and formulation strategies based on solid molecular dispersions are being exploited. Co-amorphous systems are a new formulation approach where the amorph...
7 CitationsSource
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 4
view all 3 authors...
Abstract In the present study molecular modelling was used to evaluate polymeric drug carrier matrix properties suitable for hot-melt extrusion (HME). Specifically, the effect of three commonly used plasticizers, namely, citric acid (CA), triethyl citrate (TEC) and polyethylene glycol (PEG), on Soluplus® (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer, SOL) properties were evaluated with the aid of classical molecular dynamics (MD) and docking simulations. Differenti...
5 CitationsSource
#1Anna KaragianniH-Index: 3
#2Maria MalamatariH-Index: 7
Last. Kyriakos KachrimanisH-Index: 4
view all 3 authors...
Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation. Furthermore, cocrystals of direct pharmac...
7 CitationsSource
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Agni GrypiotiH-Index: 1
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 4
view all 5 authors...
Abstract The present work describes the development of a novel formulation of amorphous agomelatine (AGM) that exhibits enhanced in vitro dissolution rate and bioavailability, as well as improved storage stability. AGM was loaded on a mixture of microcrystalline cellulose with a high specific surface area excipient, namely colloidal silicon dioxide, employing a wet granulation method, and the resultant AGM granules were subsequently formulated into immediate release film-coated tablets. Modulate...
1 CitationsSource
1